|
Adenocarcinoma of lung (disorder)
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
We detected several lung adenocarcinomas that were positive for activated p38 MAPK but evidenced reduced levels of p16Ink4a expression.
|
21164364 |
2011 |
|
Adenocarcinoma of lung (disorder)
|
0.380 |
Biomarker
|
disease |
BEFREE |
Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy.
|
21858220 |
2011 |
|
Adenocarcinoma of lung (disorder)
|
0.380 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
We demonstrate that IKKα signaling promotes increased cell malignancy of NSCLC cells as well as lung tumor progression and metastasis in either subcellular localization, through activation of common protumoral proteins, such as Erk, p38 and mTor.
|
30867890 |
2019 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
Jellyfish extract induces apoptotic cell death through the p38 pathway and cell cycle arrest in chronic myelogenous leukemia K562 cells.
|
28133573 |
2017 |
|
Lung Neoplasms
|
0.350 |
Biomarker
|
group |
BEFREE |
Furthermore, both Kras-driven mouse lung tumors and orthotopically grown primary human lung cancers show a significant sensitivity to both a chemical p38 inhibitor and an over-the-counter inhibitor of hyaluronan synthesis.
|
28007785 |
2016 |
|
Lung Neoplasms
|
0.350 |
Biomarker
|
group |
BEFREE |
Hypoxia-inducible factor-1α, pro-angiogenic protein matrix metalloproteinase 1, and VEGF are all highly expressed in Cr(VI)-transformed cells, in lung tissue from animals exposed to Cr(VI), and in lung tumor tissue from a non-smoking worker occupationally exposed to Cr(VI) for 19 years. p38 MAPK is also activated in Cr(VI)-transformed cells and in human lung tumor tissue.
|
27226640 |
2016 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
In this study, we found that treatment with ABL kinase inhibitors or depletion of BCR-ABL induced the expression of RAB45 messenger RNA and protein and induced apoptosis via reduction of mitochondrial membrane potential and p38 activation in CML cell lines and BCR-ABL(+) progenitor cells from CML patients.
|
21890458 |
2011 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
In this work we report evidences of a functional relationship between C3G and p38 MAPK in the apoptotic effect of STI-571 on the chronic myeloid leukemia (CML) cell line K562.
|
19324082 |
2009 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate that such dasatinib-dependent activation of p38 MAPK and its effectors plays a critical role in the generation of antileukemic responses, since pharmacological inhibition of p38 or siRNA-mediated knockdown of its expression reverse dasatinib-mediated apoptosis, cell cycle arrest, and anti-proliferative effects. p38 MAPK inhibition also reversed dasatinib-induced suppression of CML patient-derived leukemic colony-forming units progenitor growth in vitro, as well as BCR/ABL expressing KT-1 cell-derived leukemic progenitor growth.
|
19672773 |
2009 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
Further, we demonstrated that neither JNK2 nor p38 siRNAmediated inhibition led to significant change of CML cell proliferation.
|
17949234 |
2007 |
|
Lung Neoplasms
|
0.350 |
Biomarker
|
group |
CTD_human |
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.
|
17468755 |
2007 |
|
Myeloid Leukemia, Chronic
|
0.350 |
Therapeutic
|
disease |
CTD_human |
In other studies, we show that the small-molecule p38 inhibitors SD-282 and SCIO-469 potentiate As(2)O(3)-mediated suppression of myeloid leukemic progenitor growth from CML patients, indicating a critical regulatory role for p38 in the induction of antileukemic responses.
|
16818652 |
2006 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
LHGDN |
Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells.
|
16410245 |
2006 |
|
Lung Neoplasms
|
0.350 |
Biomarker
|
group |
BEFREE |
Examination of signaling molecules downstream of the IGF-IR showed the activation of either the Erk1/Erk2 or p38 MAPK pathways, but not both, within the lung tumors.
|
12584565 |
2003 |
|
Myocardial Ischemia
|
0.330 |
Biomarker
|
disease |
BEFREE |
Inhibiting MAPK14 (p38α) diminishes cardiac damage in myocardial ischemia.
|
30135318 |
2018 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
We hypothesized pallidin and p38 play a role in neural system development and the pathogenesis of schizophrenia, and designed several experiments to test this possibility.
|
28035416 |
2017 |
|
Liver neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
We have previously shown that the p38 MAPK inhibitor SB203580 (SB) significantly induced Cyp1a1 gene expression at the mRNA and activity levels, whereas it dramatically inhibited the induction of Cyp1a1 by TCDD in murine hepatoma Hepa 1c1c7 cells.
|
21732638 |
2011 |
|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
We also demonstrated that this new variant ss178077483, combined with mir-30e rs7556088 and mir-24-MAPK14 rs3804452, showed a weak gene-gene interaction for schizophrenia risk (P=0.001).
|
20347265 |
2010 |
|
Myocardial Ischemia
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In this model of myocardial ischemia and reperfusion, Bcl-2 expression was increased and was associated with increased p38 MAPK activation.
|
20307495 |
2010 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Variants of the mitogen-activated protein kinase 14 gene (MAPK14) and the phosphoenolpyruvate carboxykinase 1 (PCK1) and fructose-1,6-biphosphatase (FBP1) were nominal significantly associated with schizophrenia, and several haplotypes within enolase 2 gene (ENO2) consist of the same SNP allele having elevated risk of schizophrenia.
|
18460190 |
2008 |
|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Variants of the mitogen-activated protein kinase 14 gene (MAPK14) and the phosphoenolpyruvate carboxykinase 1 (PCK1) and fructose-1,6-biphosphatase (FBP1) were nominal significantly associated with schizophrenia, and several haplotypes within enolase 2 gene (ENO2) consist of the same SNP allele having elevated risk of schizophrenia.
|
18460190 |
2008 |
|
Liver neoplasms
|
0.330 |
Biomarker
|
group |
CTD_human |
p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway.
|
17468757 |
2007 |
|
Liver neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.
|
16951197 |
2006 |
|
Myocardial Ischemia
|
0.330 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |