|
Myocardial Ischemia
|
0.330 |
Biomarker
|
disease |
BEFREE |
Specific inhibition of the p38 mitogen-activated protein kinase pathway with SB 203580 almost completely blocked apoptosis mediated by pericardial fluid from ischemic heart disease.
|
11181011 |
2001 |
|
Liver neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
We analysed the involvement of MAPK homologues in IL-6 transduction pathways and found that interleukin-6 triggered activation of p38 stress-activated protein kinase (p38) but not of jun kinase. p38 activity was required for biological functions including acute phase protein secretion from HepG2 hepatoma and proliferation of B9 hybridoma cells.
|
10445852 |
1999 |
|
Depressive Symptoms
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
Altered p38 MAPK expression was associated with poor outcome in patients with esophageal cancer. p38 may be a potential biomarker for the prediction of depressive symptoms and prognosis in patients with esophageal cancer.
|
29344159 |
2017 |
|
Depressive Symptoms
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these findings indicate that sensitivity of p38 MAPK signaling pathways to immune stimulation is associated with depressive symptoms during chronic IFN-alpha treatment.
|
21356304 |
2011 |
|
Depressive Symptoms
|
0.320 |
Biomarker
|
phenotype |
PSYGENET |
Taken together, these findings indicate that sensitivity of p38 MAPK signaling pathways to immune stimulation is associated with depressive symptoms during chronic IFN-alpha treatment.
|
21356304 |
2011 |
|
Malignant neoplasm of liver
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Moreover, SATB1 expression and anoikis resistance were mainly regulated by HBV-encoded viral protein HBx through the activation of ERK and p38 MAPK signaling pathways to promote metastasis of liver cancer.
|
31147803 |
2019 |
|
Gastric Adenocarcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to examine the inhibitory effects of PlGF knockdown on cell proliferation, apoptosis and migration through p38 mitogen-activated protein kinase (p38MAPK) and PI3K pathways in human adenocarcinoma gastric cell line (AGS).
|
26968576 |
2016 |
|
Marijuana Abuse
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Of the MAPK14 tSNPs, only rs12199654 had significant genotype effects and genotype × marijuana misuse interaction effects on WM volumes. rs12199654-A homozygotes with marijuana abuse/dependence had significantly smaller total cerebral and lobar WM volumes.
|
22850347 |
2013 |
|
Marijuana Abuse
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Of the MAPK14 tSNPs, only rs12199654 had significant genotype effects and genotype × marijuana misuse interaction effects on WM volumes. rs12199654-A homozygotes with marijuana abuse/dependence had significantly smaller total cerebral and lobar WM volumes.
|
22850347 |
2013 |
|
Malignant neoplasm of liver
|
0.310 |
Biomarker
|
disease |
CTD_human |
These results demonstrate a new mechanism whereby p38alpha negatively regulates cell proliferation by antagonizing the JNK-c-Jun pathway in multiple cell types and in liver cancer development.
|
17468757 |
2007 |
|
Cardiomyopathies
|
0.310 |
Biomarker
|
group |
LHGDN |
This suggests that p38alpha MAPK is one critical downstream signal for the development of cardiomyopathy following chronic beta(2)-AR stimulation, but other kinases may be more important in ameliorating the adverse effects of chronic beta(1)-AR stimulation.
|
17446930 |
2007 |
|
Cardiomyopathies
|
0.310 |
Biomarker
|
group |
CTD_human |
Cocaine and apoptosis in myocardial cells.
|
10620750 |
1999 |
|
Gastric Adenocarcinoma
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our previous data indicated that tanshinone IIA (tan IIA) improves learning and memory in a mouse model of Alzheimer's disease (AD) induced by streptozotocin via restoring cholinergic function, attenuating oxidative stress and blocking p38 MAPK signal pathway activation.
|
31778727 |
2020 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggest that HL may have a protective effect against memory impairment and prevent oxidative stress-induced injury via the regulation of UCP4 and CyclinD1 and the modulation of JNK and P38 MAPK signaling in AD.
|
30540319 |
2019 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that cell-permeable p38 protein may be useful in preventing the degeneration of higher brain function occurring through hippocampal neuronal cell death, and furthermore, that the maintenance of intracellular p38 levels could be another therapeutic target for neurodegenerative diseases such as Alzheimer's disease (AD).
|
30735722 |
2019 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
MAPK-activated protein kinase II (MK2), downstream kinase of p38 mitogen activated protein kinase (MAPK) p38 MAPK, was unveiled as a promising option for the treatment of AD.
|
31849936 |
2019 |
|
Alzheimer's Disease
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, VB-037 demonstrated its potential to diminish LPS/IFN-γ-induced upregulation of caspase 1 activity, expression of interleukin (IL)-1β, and active phosphorylation of mitogen-activated protein kinase 14 (P38), mitogen-activated protein kinase 8 (JNK), and Jun proto-oncogene, AP-1 transcription factor subunit (JUN) signalings, as well as improve cell viability in the Tet-On Aβ-GFP SH-SY5Y AD neuronal model.
|
30707915 |
2019 |
|
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
According to RNA sequencing data, the development of AD-like pathology in OXYS rats is accompanied in the cortex by up- and downregulation of genes involved in p38 MAPK signaling.
|
30664924 |
2019 |
|
Alzheimer's Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that low-dose ionizing radiation suppresses Aβ42-induced cell death through regulation of the AKT and p38 MAPK signaling pathways, suggesting that low-dose ionizing radiation has hormetic effects on the pathogenesis of Aβ42-associated AD.
|
30670376 |
2019 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
The activation of α7nAChR or the inhibition of p38 MAPK signaling pathway may be a beneficial therapy to AD.
|
29128415 |
2018 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Until recently, many in vivo and in vitro studies have investigated the effects of p38 MAPK inhibitors in AD.
|
29804103 |
2018 |
|
Alzheimer's Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Additionally according to the reported changes of MMP-2, MMP-9 and MAPKs (ERK, P38 and JNK) in AD pathology the hippocampal contents of these proteins were determined.
|
29225190 |
2018 |
|
Cholestasis, Extrahepatic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway.
|
30026087 |
2018 |
|
Primary biliary cirrhosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P38-MAPK/NF-κB/iNOS signaling pathway.
|
30026087 |
2018 |