CSE1L, chromosome segregation 1 like, 1434

N. diseases: 163; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013146
Disease: Drug abuse
Drug abuse
0.010 Biomarker group BEFREE Specific significant associations included links between CAS and alcohol use (b = 0.40), childhood sexual abuse and unstable housing (b = - 0.75), alcohol use and childhood sexual abuse (b = 0.40), and substance use and intimate partner violence (b = 0.43). 31820288 2020
CUI: C0015300
Disease: Exophthalmos
Exophthalmos
0.010 Biomarker disease BEFREE There were significant differences in the case of exophthalmia (P=0.002), CAS (P=0.006), and Palpebral fissure (P=0.029) between the first visit and 6 months after treatment. 31345156 2020
CUI: C0015672
Disease: Fatigue
Fatigue
0.010 Biomarker phenotype BEFREE Fatigue gradually decreased after a peak at the 1st CTx cycle in Exp 2, whereas Exp 1 experienced increasing fatigue until the 3rd CTx cycle. 31129760 2020
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.010 AlteredExpression disease BEFREE Taken together, our study revealed that CSE1L inhibition decreased MITF and suppressed GPNMB expression, thereby activating the PI3K/Akt/mTOR and MEK/ERK signaling pathway, ultimately inhibiting the tumor growth and metastasis in GC. 31347172 2020
CUI: C0036690
Disease: Septicemia
Septicemia
0.010 Biomarker disease BEFREE CAS (%) is a new scoring system and works in accordance with the parameters in third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). 31823148 2020
CUI: C0037317
Disease: Sleep disturbances
Sleep disturbances
0.010 Biomarker phenotype BEFREE A gradual decrease in sleep disturbance was observed in Exp 2 after the 2nd CTx cycle, whereas Exp 1 experienced a steady increase in the symptom. 31129760 2020
CUI: C0042693
Disease: Violence
Violence
0.010 Biomarker phenotype BEFREE Specific significant associations included links between CAS and alcohol use (b = 0.40), childhood sexual abuse and unstable housing (b = - 0.75), alcohol use and childhood sexual abuse (b = 0.40), and substance use and intimate partner violence (b = 0.43). 31820288 2020
CUI: C0233705
Disease: Cancerophobia
Cancerophobia
0.010 GeneticVariation disease BEFREE This longitudinal study mapped distinct trajectories of Fear of cancer recurrence (FCR) over 12 months among patients with breast (BC) or colorectal (CRC) cancer, and examined if metacognition, indirectly via attentional bias, intrusive thoughts and avoidance (hallmarks of cognitive attentional syndrome; CAS) predicted FCR trajectory membership. 31663187 2020
CUI: C0237123
Disease: Alcohol or Other Drugs use
Alcohol or Other Drugs use
0.010 Biomarker disease BEFREE Specific significant associations included links between CAS and alcohol use (b = 0.40), childhood sexual abuse and unstable housing (b = - 0.75), alcohol use and childhood sexual abuse (b = 0.40), and substance use and intimate partner violence (b = 0.43). 31820288 2020
CUI: C0243026
Disease: Sepsis
Sepsis
0.010 Biomarker disease BEFREE CAS (%) is a new scoring system and works in accordance with the parameters in third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). 31823148 2020
CUI: C0558066
Disease: Intrusive thoughts
Intrusive thoughts
0.010 Biomarker disease BEFREE This longitudinal study mapped distinct trajectories of Fear of cancer recurrence (FCR) over 12 months among patients with breast (BC) or colorectal (CRC) cancer, and examined if metacognition, indirectly via attentional bias, intrusive thoughts and avoidance (hallmarks of cognitive attentional syndrome; CAS) predicted FCR trajectory membership. 31663187 2020
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.010 AlteredExpression disease BEFREE Taken together, our study revealed that CSE1L inhibition decreased MITF and suppressed GPNMB expression, thereby activating the PI3K/Akt/mTOR and MEK/ERK signaling pathway, ultimately inhibiting the tumor growth and metastasis in GC. 31347172 2020
CUI: C0700201
Disease: Dyssomnias
Dyssomnias
0.010 Biomarker disease BEFREE A gradual decrease in sleep disturbance was observed in Exp 2 after the 2nd CTx cycle, whereas Exp 1 experienced a steady increase in the symptom. 31129760 2020
CUI: C0851578
Disease: Sleep Disorders
Sleep Disorders
0.010 Biomarker group BEFREE A gradual decrease in sleep disturbance was observed in Exp 2 after the 2nd CTx cycle, whereas Exp 1 experienced a steady increase in the symptom. 31129760 2020
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality
0.010 Biomarker group BEFREE Cyanide produced with ethylene by ACS and its incomplete detoxification by β-CAS in mango inflorescence leads to malformation. 31797981 2019
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation
0.010 GeneticVariation disease BEFREE In conclusion, the ACE2 variant rs2074192 was associated with EH and EH with CAS ≥50%, while 3 ACE2 variants (rs4240157, rs4646155, and rs4830542) were associated with EH- and hypertension-related AF and left atrial remodeling in south Xinjiang, China. 30542083 2019
CUI: C0007780
Disease: Cerebral Embolism
Cerebral Embolism
0.010 Biomarker disease BEFREE The risk of cerebral embolism after CAS in patients with carotid IPH is still controversial. 31025147 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.010 AlteredExpression disease BEFREE The 5-item Mandarin CAS-R was associated with higher levels of self-care maintenance (β = 0.395, P < .001), management (β = 0.219, P < .01), and confidence (β = 0.524, P < .001); perceived social support (β = 0.246, P < .001); and depression (β = -0.125, P < .05). 28628499 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.010 AlteredExpression disease BEFREE The 5-item Mandarin CAS-R was associated with higher levels of self-care maintenance (β = 0.395, P < .001), management (β = 0.219, P < .01), and confidence (β = 0.524, P < .001); perceived social support (β = 0.246, P < .001); and depression (β = -0.125, P < .05). 28628499 2019
CUI: C0013362
Disease: Dysarthria
Dysarthria
0.010 Biomarker disease BEFREE <b>Abbreviations</b>: CAS: Childhood Apraxia of Speech; CD: Childhood Dysarthria; DS: Down syndrome; II: Intelligibility Index; No MSD: No Motor Speech Disorder; OII: Ordinal Intelligibility Index; PSD: Persistent Speech Delay; SDCS: Speech Disorders Classification System; SMD: Speech Motor Delay. 31221010 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.010 Biomarker disease BEFREE The aim of this study was to translate, culturally adapt, and validate the Mandarin version of the Control Attitudes Scale-Revised (Mandarin CAS-R) in Taiwanese patients with HF. 28628499 2019
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.010 Biomarker disease BEFREE The aim of this study was to translate, culturally adapt, and validate the Mandarin version of the Control Attitudes Scale-Revised (Mandarin CAS-R) in Taiwanese patients with HF. 28628499 2019
CUI: C0023055
Disease: Laryngeal neoplasm
Laryngeal neoplasm
0.010 AlteredExpression disease BEFREE The role of CSE1L expression in cervical lymph node metastasis of larynx tumors. 31383592 2019
CUI: C0028754
Disease: Obesity
Obesity
0.010 GeneticVariation disease BEFREE None of the CAS parameters were associated with any measures of obesity. 30770289 2019
CUI: C0029400
Disease: Osteitis
Osteitis
0.010 Biomarker disease BEFREE Effect of antibiotic infused calcium sulfate/hydroxyapatite (CAS/HA) insets on implant-associated osteitis in a femur fracture model in mice. 30870491 2019