CSE1L, chromosome segregation 1 like, 1434

N. diseases: 163; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0016382
Disease: Flushing
Flushing
0.010 GeneticVariation phenotype BEFREE One hundred and sixty-eight male Cobb 500 broiler chicks were used to evaluate the effect of two drying methods (freeze-dryer vs. forced air-oven) and two drying temperatures (40 vs. 55°C) (Exp 1), while ninety-six chicks were used to evaluate the effect of flushing and squeezing as well as marker types (titanium vs. chromium) on apparent ileal DM, N, Ca, P, and AA digestibility (Exp 2). 29514296 2018
CUI: C0028754
Disease: Obesity
Obesity
0.010 GeneticVariation disease BEFREE None of the CAS parameters were associated with any measures of obesity. 30770289 2019
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension
0.010 GeneticVariation disease BEFREE In conclusion, the ACE2 variant rs2074192 was associated with EH and EH with CAS ≥50%, while 3 ACE2 variants (rs4240157, rs4646155, and rs4830542) were associated with EH- and hypertension-related AF and left atrial remodeling in south Xinjiang, China. 30542083 2019
CUI: C0086692
Disease: Benign Neoplasm
Benign Neoplasm
0.010 GeneticVariation group BEFREE DNA ploidy studies were carried out on Feulgen stained smears and cytocentrifuge preparations from 35 malignant tumours and four benign neoplasms using the CAS image analyser. 1723634 1991
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.010 GeneticVariation disease BEFREE Aborted cardiac arrest was strongly associated with 2-year mortality in the CAS-AMI group (hazard ratios 13.5, 95% confidence interval 5.34 to 34.15, p <0.001) The incidence of MACE in CAS-AMI patients was significantly lower than in the CAA-AMI group of patients up to 2 years due to the relatively lower rate of repeat revascularization in CAS-AMI patients. 31547996 2019
CUI: C0233705
Disease: Cancerophobia
Cancerophobia
0.010 GeneticVariation disease BEFREE This longitudinal study mapped distinct trajectories of Fear of cancer recurrence (FCR) over 12 months among patients with breast (BC) or colorectal (CRC) cancer, and examined if metacognition, indirectly via attentional bias, intrusive thoughts and avoidance (hallmarks of cognitive attentional syndrome; CAS) predicted FCR trajectory membership. 31663187 2020
CUI: C0242231
Disease: Coronary Stenosis
Coronary Stenosis
0.010 GeneticVariation disease BEFREE Coronary artery stenosis (CAS >50% narrowing of at least one coronary artery) was detected in 223 patients (40.5%). 28766048 2018
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.010 GeneticVariation disease BEFREE Ninety-eight Feulgen stained histologic sections from patients with breast, colon, and lung cancer were measured with the CAS 200 image analysis system (Becton Dickinson, Santa Clara, CA); they included diploid (n = 42), aneuploid (n = 46), tetraploid (n = 7), and multiploid (n = 3) examples. 9056741 1997
CUI: C0333693
Disease: Triploidy syndrome
Triploidy syndrome
0.010 GeneticVariation disease BEFREE At the same time, the DNA content of the 46 specimens was quantified cytophotometrically using the CAS 200 image analyzer, in order to confirm or not the diagnosis of triploidy. 8927563 1995
CUI: C0497550
Disease: Benign neurologic neoplasms
Benign neurologic neoplasms
0.010 GeneticVariation group BEFREE DNA ploidy studies were carried out on Feulgen stained smears and cytocentrifuge preparations from 35 malignant tumours and four benign neoplasms using the CAS image analyser. 1723634 1991
CUI: C0577631
Disease: Carotid Atherosclerosis
Carotid Atherosclerosis
0.010 GeneticVariation disease BEFREE All subjects were included either in the carotid atherosclerosis (AS) group or the control group according to the CAS diagnosis criteria. 30186852 2018
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.010 GeneticVariation disease BEFREE Ninety-eight Feulgen stained histologic sections from patients with breast, colon, and lung cancer were measured with the CAS 200 image analysis system (Becton Dickinson, Santa Clara, CA); they included diploid (n = 42), aneuploid (n = 46), tetraploid (n = 7), and multiploid (n = 3) examples. 9056741 1997
CUI: C0936223
Disease: Metastatic Prostate Carcinoma
Metastatic Prostate Carcinoma
0.010 GeneticVariation disease BEFREE The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors. 20470445 2010
Metastasis from malignant tumor of prostate
0.010 GeneticVariation disease BEFREE The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors. 20470445 2010
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.010 GeneticVariation disease BEFREE Ninety-eight Feulgen stained histologic sections from patients with breast, colon, and lung cancer were measured with the CAS 200 image analysis system (Becton Dickinson, Santa Clara, CA); they included diploid (n = 42), aneuploid (n = 46), tetraploid (n = 7), and multiploid (n = 3) examples. 9056741 1997
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.010 GeneticVariation phenotype BEFREE The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors. 20470445 2010
CUI: C1527349
Disease: Ductal Breast Carcinoma
Ductal Breast Carcinoma
0.010 GeneticVariation disease BEFREE We analyzed 25 cases of archived, paraffin-embedded breast carcinoma (ductal) for Feulgen stain DNA analysis and MIB-1 immunohistochemistry using the CAS 200 Image Cytometer. 9142183 1997
CUI: C3266262
Disease: Multiple Chronic Conditions
Multiple Chronic Conditions
0.010 GeneticVariation disease BEFREE Our objective was to determine the generalizability of the CAS-15 in a multi-institutional fashion. 31782808 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 Biomarker disease BEFREE The upregulation of karyopherin α 2 (KPNA2) and chromosome segregation 1‑like (CSE1L) in colorectal carcinoma, in addition to downregulation of chloride channel accessory 1 (CLCA1), fatty acid binding protein 1 (FABP1), sodium channel, voltage gated, type VII α subunit (SCN7A) and solute carrier family 26 (anion exchanger), member 3 (SLC26A3) was confirmed. 27121919 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 Biomarker disease BEFREE CSE1L, DIDO1 and RBM39 are located on the 20q amplicon and affect processes such as cell viability and anchorage-independent growth in colorectal cancer. 22711543 2012
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 Biomarker disease BEFREE CSE1L was significantly increased during the transition from AD to CRC when compared with NR in a CRC tissue microarray (P = 0.01 and P < 0.001). 27521996 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.360 Biomarker disease BEFREE Immunohistochemistry of a colorectal cancer tissue microarray showed that CSE1L had a significantly increased level in colorectal cancer compared to normal colorectal epithelium (p < 0.001). 22450763 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE The combination of CTNB1, XPO2, and CAPG achieved 95% sensitivity and 96% specificity for the discrimination of these subtypes.<b>Conclusions:</b> We developed two uterine aspirate-based signatures to diagnose EC and classify tumors in the most prevalent histologic subtypes. 28790116 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Thus, CAS/Crk assembly serves as a "molecular switch" for the induction of cell migration and appears to contribute to the invasive property of tumors. 9472046 1998
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE In neoplastic tissue, CAS was present in 93% of the tumors, Bax in 88%, caspase-3 in 77%, and Bcl-2 in 51%. 11603220 2001