|
Tuberculosis
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In Kampala, Uganda, there are three sub-lineages of M. tuberculosis lineage 3 that cause disease of comparable severity with CAS-Dehli as the most prevalent.
|
31498808 |
2019 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Available associated information on gender (n = 18,944), age (n = 16,968), drug resistance (n = 19,606), and HIV serology (n = 2673), allowed to draw some important conclusions on TB geo-epidemiology; e.g. a positive correlation exists between certain Mycobacterium tuberculosis lineages (such as CAS and Beijing) and drug resistance (p-value<.001), while other lineages (such as LAM, X, and BOV) are more frequently associated with HIV-positive serology (p-value<.001).
|
30593925 |
2019 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to determine in vitro, the susceptibility patterns of M. tuberculosis Uganda family compared with Beijing and Delhi/CAS, other M. tuberculosis sub-lineages that also circulate in Uganda but are not as prevalent.
|
27097724 |
2016 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
The most frequent superfamily of M tuberculosis in clinical isolates was Delhi/CAS (142, 30.3%) followed by NEW-1 (127, 27%).
|
25340935 |
2015 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Moreover, high congruence between the MIRU-VNTR-based and spoligotyping-based strain groupings suggests that CAS, EAI and Beijing are the predominant strain lineages in the Mumbai TB patient population.
|
22321730 |
2012 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
The most frequent M. tuberculosis lineage was Lineage 3 (CAS/Delhi) with 106 isolates (40.6%), followed by Lineage 2 (East-Asian lineage, includes Beijing genotype) with 84 isolates (32.2%), Lineage 4 (Euro-American lineage) with 41 (15.7%) isolates, and Lineage 1 (Indo-Oceanic lineage) with 30 isolates (11.5%).
|
23300635 |
2012 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
Two STs; ST26 (CAS_Delhi) and ST1 (Beijing) represented 36.1% of the total M. tuberculosis population in eastern Uttar Pradesh, North India.
|
18372222 |
2008 |
|
Tuberculosis
|
0.080 |
Biomarker
|
disease |
BEFREE |
The observed distribution of genotypes shows that principal genetic group 1 strains (EAI, Beijing, CAS, Afri, "Manu") is high (35.4%) suggesting an ancient evolutionary history of tuberculosis in Madagascar, in relation to the origin of peopling and the demographic history.
|
16168940 |
2005 |