CSF1, colony stimulating factor 1, 1435

N. diseases: 259; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027859
Disease: Acoustic Neuroma
Acoustic Neuroma
0.010 AlteredExpression disease BEFREE Immunohistochemical expression of M-CSF and IL-34 was analyzed in ten fast-growing vestibular schwannomas and in ten slow-growing vestibular schwannomas. 30580386 2019
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.010 Biomarker disease BEFREE By contrast, detectable CSF-1 receptors were uniformly absent on blasts from 19 children with acute lymphoblastic leukemia. 2465043 1989
CUI: C0023479
Disease: Acute myelomonocytic leukemia
Acute myelomonocytic leukemia
0.010 AlteredExpression disease BEFREE M-CSF and M-CSF-receptor gene expression in acute myelomonocytic leukemias. 2154646 1990
CUI: C0001342
Disease: Acute periodontitis
Acute periodontitis
0.020 GeneticVariation disease BEFREE Among these, three polymorphisms located in the colony stimulating factor 1 (CSF1) gene showed a positive association with AgP. 16844084 2006
CUI: C0001342
Disease: Acute periodontitis
Acute periodontitis
0.020 Biomarker disease BEFREE Thus, this study aims to evaluate levels of the innate immunity-related markers calprotectin, colony-stimulating factor (CSF)-1, macrophage migration inhibitory factor (MIF), monokine induced by interferon-γ (MIG), and matrix metalloproteinase (MMP)-8 in serum and saliva from patients with generalized AgP and those with gingivitis or a healthy periodontium. 28753101 2017
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.040 AlteredExpression group BEFREE Recent studies have demonstrated overexpression of CSF-1 and its receptor in breast, ovarian, and endometrial adenocarcinomas. 9815987 1995
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.040 Biomarker group BEFREE Co-expression of M-CSF transcripts and protein, FMS (M-CSF receptor) transcripts and protein, and steroid receptor content in adenocarcinomas of the ovary. 7965406 1994
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.040 AlteredExpression group BEFREE Because about half (6/14) of the invasive adenocarcinoma specimens were shown to coexpress fms and colony-stimulating factor 1, the authors propose that the expression of this lymphohematopoietic cytokine and its receptor by ovarian adenocarcinomas could contribute to their proliferative and invasive characteristics in vivo. 1695482 1990
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.040 AlteredExpression group BEFREE A high expression of CSF1 correlated with shorter metastasis-free survival in the entire NSCLC group (P = .016) and in SCC (P = .049) and AC (P = .034) cohorts. 23870818 2013
CUI: C0220597
Disease: Adult Hodgkin Lymphoma
Adult Hodgkin Lymphoma
0.010 Biomarker disease BEFREE During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)/colony stimulating factor 1 (CSF1) region. 31731509 2019
CUI: C0278607
Disease: Adult Leiomyosarcoma
Adult Leiomyosarcoma
0.010 AlteredExpression disease BEFREE CSF1 expression in nongynecological leiomyosarcoma is associated with increased tumor angiogenesis. 21854753 2011
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma
0.010 Biomarker disease BEFREE A novel CSF-1 binding factor in a patient in complete remission following cytotoxic therapy for lymphoma. 7833270 1995
CUI: C0280099
Disease: Adult Solid Neoplasm
Adult Solid Neoplasm
0.010 Biomarker group BEFREE The suppression of CSF-1 by RNA interference is therefore a powerful tool to block gene function and influence tumor-stroma interactions in solid tumor development. 17172715 2007
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis
0.020 GeneticVariation disease BEFREE Among these, three polymorphisms located in the colony stimulating factor 1 (CSF1) gene showed a positive association with AgP. 16844084 2006
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis
0.020 Biomarker disease BEFREE Thus, this study aims to evaluate levels of the innate immunity-related markers calprotectin, colony-stimulating factor (CSF)-1, macrophage migration inhibitory factor (MIF), monokine induced by interferon-γ (MIG), and matrix metalloproteinase (MMP)-8 in serum and saliva from patients with generalized AgP and those with gingivitis or a healthy periodontium. 28753101 2017
CUI: C0001925
Disease: Albuminuria
Albuminuria
0.200 Therapeutic phenotype RGD The effect of macrophage colony-stimulating factor (M-CSF) on the progression of lipid-induced nephrotoxicity in diabetic nephropathy. 8573750 1996
CUI: C1864828
Disease: ALZHEIMER DISEASE 10
ALZHEIMER DISEASE 10
0.020 AlteredExpression disease BEFREE MDR human ovarian cancer (AD10) cells were transduced with the human M-CSF gene inserted into an expression vector to establish gene-modified cells capable of producing low (ML-AD10), intermediate (MM-AD10) nd high (MH-AD10) amounts of M-CSF. 8698627 1996
CUI: C1864828
Disease: ALZHEIMER DISEASE 10
ALZHEIMER DISEASE 10
0.020 Biomarker disease BEFREE A human macrophage-colony-stimulating-factor (M-CSF) gene inserted into an expression vector (pRc/CMV-MCSF) was transfected into multidrug-resistant (MDR) human ovarian cancer cells (AD10) to induce secretion of human M-CSF into the medium. 8100809 1993
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.030 Biomarker disease LHGDN We assessed if genetic variability of CSF1 may influence the risk for AD. 17192722 2006
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.030 Biomarker disease BEFREE We assessed if genetic variability of CSF1 may influence the risk for AD. 17192722 2006
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.030 AlteredExpression disease BEFREE Using human brain samples [inferior temporal gyrus (ITG) and middle temporal gyrus (MTG)] from distinct cohorts of AD, control and high pathology, or mild cognitive impairment cases, we showed that there was increased expression of CSF-1R and CSF-1 mRNAs in both series of AD cases, and reduced expression of IL-34 mRNA in AD ITG samples. 28848420 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.030 Biomarker disease BEFREE We discovered that systemic administration of human recombinant CSF1 ameliorates memory deficits in a transgenic mouse model of Alzheimer's disease. 23296467 2013
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.010 AlteredExpression disease BEFREE Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating factor 1 correlate with disease activity in ankylosing spondylitis. 15478146 2004
CUI: C0003130
Disease: Anoxia
Anoxia
0.010 Biomarker phenotype LHGDN Elevation of serum macrophage colony-stimulating factor before the clinical manifestations of preeclampsia. 14634568 2003
Anti-Basement Membrane Glomerulonephritis
0.200 Therapeutic disease RGD Preventive and therapeutic effects of imatinib in Wistar-Kyoto rats with anti-glomerular basement membrane glomerulonephritis. 19242505 2009