|
Ataxia Telangiectasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We created a 51-point ATFS, that consisted of three ambulation items adapted for ataxia telangiectasia in the frame of FMS (home, school, outdoors), five ADL items, and one schooling item.
|
31468510 |
2020 |
|
Huntington Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To address the role of these cells in disease pathogenesis, we depleted microglia from R6/2 mice, a rapidly progressing model of Huntington's disease marked by behavioural impairment, mutant huntingtin (mHTT) accumulation, and early death, through colony-stimulating factor 1 receptor inhibition (CSF1Ri) with pexidartinib (PLX3397) for the duration of disease.
|
31848580 |
2020 |
|
Retinal Vein Occlusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
To test this hypothesis, we depleted microglia by PLX5622 (a selective tyrosine kinase inhibitor that targets the colony-stimulating factor-1 receptor) in fractalkine receptor reporter mice (Cx3cr1<sup>gfp/+</sup> ) subjected to various regimens of PLX5622 treatment and experimental RVO.
|
31652020 |
2020 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CSF1R inhibition is a promising new target for the treatment of allergic asthma.
|
31385613 |
2020 |
|
Exudative age-related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that CSF-1R inhibition may be a novel therapeutic target in patients with neovascular age-related macular degeneration.
|
31783006 |
2020 |
|
Involuntary Movements
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
It also showed that involuntary movements and brainstem or cerebellar atrophy were negative predictors of a CSF1R-mutation-positive result.
|
31520500 |
2020 |
|
Cutaneous/peripheral T-cell lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed that CSF1R is aberrantly expressed in many T-cell lymphomas, including a significant number of peripheral and cutaneous T-cell lymphomas.
|
31636099 |
2020 |
|
Cerebellar atrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It also showed that involuntary movements and brainstem or cerebellar atrophy were negative predictors of a CSF1R-mutation-positive result.
|
31520500 |
2020 |
|
Amnesia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The mother and two elderly siblings of the proband had the same CSF1R mutation as the proband but showed very mild neuroimaging abnormalities and mild memory loss, which did not affect daily life, indicating very uneven penetrance and distinctly different disease progression among family members.
|
31191609 |
2019 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CRPS and FMS had pressure hyperalgesia in the index arm relative to arthritis patients.
|
31408010 |
2019 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined transcriptional data from CD mucosa for evidence of CSF-1 pathway activation and tested JNJ-40346527 (PRV-6527), a small molecule inhibitor of CSF-1 receptor kinase (CSF-1R), for its ability to inhibit disease indices in murine colitis.
|
31710624 |
2019 |
|
Cytomegalovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We evidenced that deliberate QKI5 overexpression in the absence of HCMV infection context is able to decrease CSF-1R and RANK expression, leading to osteoclastogenesis inhibition.
|
31834954 |
2019 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
BMP7, CD55, CSF1R, INHBC and F5 are likely to take crucial roles in the pathogenesis of DN.
|
30988245 |
2019 |
|
Diphtheria
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both the administration of systemic diphtheria toxin or anti-CSF-1R blocking antibody result in highly efficient and reversible depletion of microglia population in the CNS, which can be easily assessed by flow cytometry.
|
31392688 |
2019 |
|
Fibromyalgia
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to identify relationships between sensory function and pain in 3 common pain conditions (arthritis, Complex Regional Pain Syndrome [CRPS] and fibromyalgia syndrome [FMS]) and pain-free participants.
|
31408010 |
2019 |
|
Graft-vs-Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using multiple murine GVHD/GVL models including both MHC-mismatched and miHA-mismatched, we demonstrated that treatment with CD115+ MDSCs efficiently suppressed GVHD but did not significantly impair graft-versus-leukemia (GVL) activity, leading to 80 and 67% protection in treated mice in GVHD and GVL models, respectively.
|
30737483 |
2019 |
|
Hemophilia A
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We confirmed an association of CSF1R rs17725712 and MAPK9 rs4147385 with inhibitor development in haemophilia A patients in North China.
|
31149782 |
2019 |
|
Histiocytosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we uncovered activating mutations in CSF1R and rearrangements in RET and ALK that conferred dramatic responses to selective inhibition of RET (selpercatinib) and crizotinib, respectively, in patients with histiocytosis.
|
31768065 |
2019 |
|
HIV Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Overexpression and activation of colony-stimulating factor 1 receptor in the SIV/macaque model of HIV infection and neuroHIV.
|
31033097 |
2019 |
|
Hyperalgesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
CRPS and FMS had pressure hyperalgesia in the index arm relative to arthritis patients.
|
31408010 |
2019 |
|
Hyperesthesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Relative to pain-free participants, FMS displayed heat hyperesthesia in both arms and cold hyperesthesia in the contralateral arm.
|
31408010 |
2019 |
|
Malaria
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that a subset of liver-infiltrating monocyte-derived CD11c<sup>+</sup> cells co-expressing F4/80, CD103, CD207, and CSF1R acquired parasites during the liver stage of malaria, but only after initial hepatocyte infection.
|
30905437 |
2019 |
|
Premature Menopause
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An Autopsy Proven Case of CSF1R-mutant Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) with Premature Ovarian Failure.
|
30853829 |
2019 |
|
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
PTPN2 and CSF1R are potential targets for the therapy of diabetic periodontitis or other bone loss-related diseases.
|
31373168 |
2019 |
|
Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association between CSF1 and CSF1R Polymorphisms and Parkinson's Disease in Taiwan.
|
31554150 |
2019 |