|
Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
PTPN2 and CSF1R are potential targets for the therapy of diabetic periodontitis or other bone loss-related diseases.
|
31373168 |
2019 |
|
West Nile Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mice treated with CSF1R antagonist prior to infection exhibited higher susceptibility to lethal WNV infection and lack of virologic control in both the CNS and periphery.
|
30704498 |
2019 |
|
Lentivirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In the present study, we investigated whether colony-stimulating factor 1 receptor (CSF1R) is expressed on brain macrophages and microglia in the human and macaque brain and whether it is upregulated and activated after lentivirus infection in vivo and contributes to development of encephalitic lesions.
|
31033097 |
2019 |
|
Ovarian Failure, Premature
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An Autopsy Proven Case of CSF1R-mutant Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) with Premature Ovarian Failure.
|
30853829 |
2019 |
|
Encephalopathies
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation.
|
30982609 |
2019 |
|
Intervertebral Disc Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased colony-stimulating factor 1/colony-stimulating factor 1 receptor signaling is involved in the disc degeneration-induced microglia activation and back pain.
|
30326776 |
2019 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
CSF1R and BTK inhibitions as novel strategies to disrupt the dialog between mantle cell lymphoma and macrophages.
|
30940906 |
2019 |
|
Histiocytic syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we uncovered activating mutations in CSF1R and rearrangements in RET and ALK that conferred dramatic responses to selective inhibition of RET (selpercatinib) and crizotinib, respectively, in patients with histiocytosis.
|
31768065 |
2019 |
|
Dysosteosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation.
|
30982609 |
2019 |
|
Memory Loss
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The mother and two elderly siblings of the proband had the same CSF1R mutation as the proband but showed very mild neuroimaging abnormalities and mild memory loss, which did not affect daily life, indicating very uneven penetrance and distinctly different disease progression among family members.
|
31191609 |
2019 |
|
Lewy Body Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We present a case of a patient with a pathogenic variant in the CSF1R gene with clinical and imaging features suggestive of Dementia with Lewy Bodies (DLB).
|
30968732 |
2019 |
|
Tauopathies
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In this study, we tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 (JNJ-527) in the P301S mouse tauopathy model.
|
31504240 |
2019 |
|
West Nile viral infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Pharmacological inactivation of CSF1R was achieved using PLX5622 prior to infection with virulent or attenuated strains of West Nile virus (WNV), an emerging neuropathogen.
|
30704498 |
2019 |
|
Compensatory Hyperinsulinemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We used chemical (clodronate), genetics (CD169-diphtheria toxin receptor mice), or antibody-mediated (colony-stimulating factor 1 receptor α) macrophage ablation methods in diabetic (db/db) and diet-induced models of compensatory hyperinsulinemia to investigate the role of macrophages in islet remodeling.
|
31573842 |
2019 |
|
Liver regeneration disorder
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
However, the expression of Csf1r and Mer on KC subsets and the importance of these tyrosine kinases during liver regeneration (LR) are unknown.
|
31042769 |
2019 |
|
Cerebral hypoperfusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we used PLX3397, a colony-stimulating factor 1 receptor inhibitor, to deplete microglia in mice with chronic cerebral hypoperfusion induced by bilateral common carotid artery stenosis (BCAS).
|
31097227 |
2019 |
|
Executive dysfunction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we address for the first time preclinical topics crucial for translation, most importantly <i>1</i>) the comparison of 2 long-term PLX5622 applications (prevention and treatment) <i>vs.</i> 1 treatment alone, <i>2</i>) the correlation of catatonic signs and executive dysfunction, <i>3</i>) the phenotype of leftover microglia evading depletion, and <i>4</i>) the role of intercellular interactions for efficient CSF1R inhibition.
|
31090455 |
2019 |
|
Behavioral and psychological symptoms of dementia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
<i>CSF1R</i>-related leukoencephalopathy, also known as hereditary diffuse leukoencephalopathy with spheroids (HDLS), is a rare white-matter encephalopathy characterized by motor and neuropsychiatric symptoms due to colony-stimulating factor 1 receptor (<i>CSF1R</i>) gene mutation.
|
31827782 |
2019 |
|
Mantle cell lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we showed that targeting the CSF1R abrogated MϕMCL-dependent MCL survival, irrespective of their sensitivity to ibrutinib.
|
30940906 |
2019 |
|
Anxiety
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, microglial depletion with a CSF1R antagonist prior to stress prevented the recruitment of monocytes to the brain and abrogated the development of anxiety.
|
28373688 |
2018 |
|
Anxiety Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Moreover, microglial depletion with a CSF1R antagonist prior to stress prevented the recruitment of monocytes to the brain and abrogated the development of anxiety.
|
28373688 |
2018 |
|
Bone Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Colony stimulation factor-1 receptor (CSF-1R), which is also known as FMS kinase, plays an important role in initiating inflammatory, cancer, and bone disorders when it is overstimulated by its ligand, CSF-1.
|
29293000 |
2018 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
No correlation was found between eotaxin-2 and severity measures of FMS or depression.<i>Conclusion</i>.
|
29861805 |
2018 |
|
Eclampsia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Prognostic value of serum soluble FMS-like tyrosine kinase (sFlt-1) levels in pre-eclampsia and eclampsia; a prospective cohort study.
|
30032672 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
In vivo, neuroblastomas formed by subcutaneous co-injection of human neuroblastoma cells and human monocytes into immunodeficient NOD/SCID mice had fewer human CD14<sup>+</sup> and CD163<sup>+</sup> cells and mouse F4/80<sup>+</sup> cells after CSF-1R blockade.
|
29665011 |
2018 |