leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
SIGNIFICANCE: This study reveals the critical importance of membrane-proximal N-linked glycosylation of CSF3R for the maintenance of ligand dependency in leukemia.
|
30348809 |
2018 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, the aim of this study was to investigate the effects of Shb knockout on the development of leukemia in three additional models, that is, colony stimulating factor 3 receptor-T618I-induced neutrophilic leukemia, p190 Breakpoint cluster region-cAbl oncogene 1 tyrosine kinase-induced B-cell leukemia, and G12D-Kras-induced T-cell leukemia/thymic lymphoma.
|
29792386 |
2018 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Overall, our results show the structural and functional importance of conserved extracellular cysteine pairs in CSF3R and suggest the necessity for broader screening of CSF3R extracellular domain in leukemia patients.<i></i>.
|
28652245 |
2017 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Enhanced MAPK signaling is essential for CSF3R-induced leukemia.
|
28031554 |
2017 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The time between the first detection of CSF3R mutations and overt leukemia is highly variable.
|
27270496 |
2016 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Chemical interrogation of these primary human specimens revealed a uniform and specific sensitivity to all JAK inhibitors tested irrespective of their CSF3R mutation status, indicating a general sensitization of JAK-STAT signaling in this leukemia subset.
|
27034432 |
2016 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sanger sequencing of leukemia samples was performed to identify CSF3R mutations in CNL and aCML.
|
26475333 |
2016 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings raised the questions how CSF3R mutations affect CSF3 responses of myeloid progenitors, how they contribute to the pre-leukemic state of SCN, and which additional events are responsible for progression to leukemia.
|
26637693 |
2015 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the CSF3 granulocyte colony-stimulating factor receptor CSF3R have recently been found in a large percentage of patients with chronic neutrophilic leukemia and, more rarely, in other types of leukemia.
|
24403076 |
2014 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The detection of both RUNX1 and CSF3R mutations could be used as a marker for identifying CN patients with a high risk of progressing to leukemia or MDS.
|
24523240 |
2014 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Granulocyte-colony stimulating factor receptor (G-CSFR) mutations have been implicated in the progression of severe congenital neutropenia (SCN) to leukemia.
|
24746896 |
2014 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The G-CSFR has also been implicated in the etiology of disease, with mutations/variants of G-CSFR implicated in neutropenia, myelodysplasia and leukemia.
|
19699815 |
2009 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
G-CSF receptor mutations in patients with congenital neutropenia.
|
18536571 |
2008 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Point mutations in the gene for the granulocyte colony-stimulating factor (G-CSF) receptor CSF3R have been implicated in the progression of severe congenital neutropenia (CN) to leukemia.
|
16985178 |
2007 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Congenital neutropenia patients with acquired granulocyte colony-stimulating factor receptor mutations define a group with high risk for development of leukemia.
|
17133096 |
2007 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data are the first to document leukemia evolution and G-CSFR gene mutations in the original Kostmann kindred.
|
16670064 |
2006 |
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because we also found preferential constitutive STAT5B activation after transformation of cells by a truncated form of the G-CSF-R that produces severe neutropenia (Kostmann syndrome) and favors leukemia in humans, we discuss the potential role of STAT5B in oncogenic transformation of hematopoietic cells.
|
15677477 |
2005 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because SCN patients with a mutation in the G-CSF receptor frequently develop leukemia, this 3-base pair deletion in the juxtamembrane sequence of the G-CSF receptor gene in this patient may be one step in the course of leukemic transformation.
|
16229088 |
2005 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Acute myeloid/NK precursor cell leukemia with trisomy 4 and a novel point mutation in the extracellular domain of the G-CSF receptor in a patient with chronic idiopathic neutropenia.
|
15014900 |
2004 |
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Time course of increasing numbers of mutations in the granulocyte colony-stimulating factor receptor gene in a patient with congenital neutropenia who developed leukemia.
|
11238134 |
2001 |
leukemia
|
0.400 |
CausalMutation
|
disease |
CGI |
|
|
|