CSN2, casein beta, 1447

N. diseases: 49; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.300 Biomarker group CTD_human Carcinomas showed relatively high expression of several genes associated with mammary epithelial cell growth and proliferation (e.g., cyclin D1, PDGFalpha) and relatively low expression of differentiation marker genes (e.g., beta -casein, whey acidic protein, transferrin). 16316942 2005
CUI: C0024667
Disease: Animal Mammary Neoplasms
Animal Mammary Neoplasms
0.300 Biomarker phenotype CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental
0.300 Biomarker phenotype CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0205696
Disease: Anaplastic carcinoma
Anaplastic carcinoma
0.300 Biomarker disease CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0205697
Disease: Carcinoma, Spindle-Cell
Carcinoma, Spindle-Cell
0.300 Biomarker disease CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0205698
Disease: Undifferentiated carcinoma
Undifferentiated carcinoma
0.300 Biomarker disease CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0205699
Disease: Carcinomatosis
Carcinomatosis
0.300 Biomarker phenotype CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C1257925
Disease: Mammary Carcinoma, Animal
Mammary Carcinoma, Animal
0.300 Biomarker disease CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.300 Biomarker group CTD_human In addition, carcinomas from animals on the high-fat diet showed on average a 5-fold higher expression of beta-casein and transferrin than carcinomas from animals on the low-fat diet. 9879772 1998
CUI: C0024667
Disease: Animal Mammary Neoplasms
Animal Mammary Neoplasms
0.300 Biomarker phenotype CTD_human mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors. 9879772 1998
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental
0.300 Biomarker phenotype CTD_human mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors. 9879772 1998
CUI: C0205696
Disease: Anaplastic carcinoma
Anaplastic carcinoma
0.300 Biomarker disease CTD_human mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors. 9879772 1998
CUI: C0205697
Disease: Carcinoma, Spindle-Cell
Carcinoma, Spindle-Cell
0.300 Biomarker disease CTD_human mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors. 9879772 1998
CUI: C0205698
Disease: Undifferentiated carcinoma
Undifferentiated carcinoma
0.300 Biomarker disease CTD_human mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors. 9879772 1998
CUI: C0205699
Disease: Carcinomatosis
Carcinomatosis
0.300 Biomarker phenotype CTD_human mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors. 9879772 1998
CUI: C1257925
Disease: Mammary Carcinoma, Animal
Mammary Carcinoma, Animal
0.300 Biomarker disease CTD_human mRNA differential display of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors. 9879772 1998
Diabetes Mellitus, Insulin-Dependent
0.040 GeneticVariation disease BEFREE The contribution of cows' milk containing beta-casein protein A1 variant to the development of type 1 diabetes (T1D) has been controversial for decades. 30213104 2018
Diabetes Mellitus, Insulin-Dependent
0.040 GeneticVariation disease BEFREE It seems that the populations that consume milk containing high levels of beta-casein A2 have a lower incidence of cardiovascular disease and type 1 diabetes. 17666771 2007
Diabetes Mellitus, Insulin-Dependent
0.040 Biomarker disease BEFREE The highest antibody response to beta-casein in Type 1 diabetic patients and in patients with coeliac disease could reflect the gut mucosal immune disorders common to Type 1 diabetes and coeliac disease. 12198602 2002
Diabetes Mellitus, Insulin-Dependent
0.040 Biomarker disease BEFREE We analysed cellular immune reactivities against beta casein in newly-diagnosed Type I diabetic patients, their immediate autoantibody negative relatives, and unrelated healthy individuals in order to further elucidate the role of anti-beta casein immunity in the pathogenesis of Type I diabetes mellitus. 9662058 1998
CUI: C0022951
Disease: Lactose Intolerance
Lactose Intolerance
0.030 Biomarker disease BEFREE Furthermore, self-reported dairy intolerance without LM (NLDI) is characterized by early-onset digestive discomfort following milk ingestion, irrespective of lactose content or β-casein type. 31773165 2020
CUI: C0022951
Disease: Lactose Intolerance
Lactose Intolerance
0.030 Biomarker disease BEFREE In this study, we hypothesized that replacing conventional milk, which contains A1 and A2 β-casein proteins, with milk that contains only A2 β-casein in the diet of dairy or milk-intolerant preschoolers (age 5 to 6 years) would result in reduced gastrointestinal symptoms associated with milk intolerance, and that this would correspond with cognitive improvements. 31305326 2019
CUI: C0022951
Disease: Lactose Intolerance
Lactose Intolerance
0.030 GeneticVariation disease BEFREE Effects of cow's milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study. 29070042 2017
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.030 Biomarker group BEFREE The goal of work was identification A1 variant of bovine beta casein which involves ischemic heart disease and diabetes mellitus in human. 24432335 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 AlteredExpression group BEFREE Analysis of SIM2s-MCF10DCIS.com tumors showed that SIM2s promoted a more differentiated tumor phenotype including the expression of a broad range of luminal markers (CSN2 (β-casein), CDH1 (E-cadherin), and KER18 (keratin-18)) and suppressed genes associated with stem cell maintenance and a basal phenotype (SMO (smoothened), p63, SLUG (snail-2), KER14 (keratin-14) and VIM (vimentin)). 22777354 2013