LACC1, laccase domain containing 1, 144811

N. diseases: 35; N. variants: 2
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease BEFREE More recently, mutations in LACC1 (laccase domain-containing protein 1) have been identified as the cause of a monogenic form of systemic juvenile idiopathic arthritis, which does not itself manifest granulomatous inflammation, but the same LACC1 mutations have also been shown to cause an early-onset, familial form of a well-known granulomatous condition, Crohn's disease (CD). 29538758 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 Biomarker disease BEFREE Relative to LACC1 Ile254, cells transfected with Crohn's disease-risk LACC1 Val254 or LACC1 with mutations of the nearby histidines (249,250) have reduced PRR-induced outcomes. 28593945 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 Biomarker disease BEFREE Functional Analyses of the Crohn's Disease Risk Gene LACC1. 27959965 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease BEFREE Single-nucleotide variations in C13orf31 (LACC1) that encode p.C284R and p.I254V in a protein of unknown function (called 'FAMIN' here) are associated with increased risk for systemic juvenile idiopathic arthritis, leprosy and Crohn's disease. 27478939 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease BEFREE We tested the hypothesis that LACC1 single nucleotide polymorphisms (SNPs), in addition to CD, are associated with juvenile idiopathic arthritis (JIA, non-systemic), and another major form of inflammatory bowel disease, ulcerative colitis (UC). 27098602 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 Biomarker disease BEFREE Association of LACC1 with Crohn's disease and leprosy has been reported and justifies investigation of its role in autoinflammatory disorders. 25220867 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 Biomarker disease BEFREE Further analysis of the newly discovered association suggested that 13 genes, such as ATG16L1 and LACC1, may play an important role in CD pathophysiological and etiological processes. 23135745 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease GWASDB Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. 23128233 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease GWASCAT Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. 23128233 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease GWASCAT Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease GWASDB Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease GWASCAT Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease GWASDB Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008