VCAN, versican, 1462

N. diseases: 205; N. variants: 16
Disease: Dilatation of aorta ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0265004
Disease: Dilatation of aorta
Dilatation of aorta 		0.020 Biomarker phenotype BEFREE A similar increase in ADAMTS-1 was observed in aortas of AngII-treated Adamts5<sup>Δcat</sup> mice but was not sufficient to maintain versican processing and prevent aortic dilatation. 29622560 2018
CUI: C0265004
Disease: Dilatation of aorta
Dilatation of aorta 		0.020 Biomarker phenotype BEFREE It is proposed that the decreased synthesis and increased degradation of versican, particularly of isoform V(0), and the resulting low concentration in the intima are crucial factors contributing to the altered viscoelastic and compressive properties and thereby to the deformity and dilatation of aorta. 11166769 2001