ADRA1A, adrenoceptor alpha 1A, 148

N. diseases: 294; N. variants: 30
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.030 Biomarker disease BEFREE Deficiency of phosphodiesterase 4A (PDE4A), an enzyme that degrades cAMP and modulates stimulatory regulative G protein (Gs)-coupled G protein-coupled receptor signaling, protected animals either from genetic- or dietary-induced depression phenotype. 31076569 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.030 Biomarker disease BEFREE These data provide a strong impetus for validation studies using a larger cohort and support the possibility that G-protein coupled receptor protein signaling pathways are involved in the pathogenesis of depression. 29305581 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.030 Biomarker disease BEFREE Regulation of G-protein coupled receptor signalling underpinning neurobiology of mood disorders and depression. 28229904 2017