|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Kaposi's sarcoma-associated herpesvirus G-protein-coupled receptor (vGPCR) is a key molecule in the pathogenesis of Kaposi's sarcoma.
|
31838186 |
2020 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antineoplastic effect of 1α,25(OH)<sub>2</sub>D<sub>3</sub> in spheroids from endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus G protein coupled receptor.
|
30308321 |
2019 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antiproliferative effects of Bortezomib in endothelial cells transformed by viral G protein-coupled receptor associated to Kaposi's sarcoma.
|
28161489 |
2017 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
KSHV genome contains several oncogenes, among which, the viral G-protein-coupled receptor (vGPCR open reading frame 74) has emerged as a major factor in KS pathogenicity.
|
24292677 |
2014 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Kaposi's Sarcoma-associated Herpesvirus (KSHV)-encoded G-protein coupled receptor (vGPCR) is an oncoprotein that is implicated in KSHV-associated malignancies.
|
23269549 |
2013 |
|
Kaposi Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lymphatic reprogramming by Kaposi sarcoma herpes virus promotes the oncogenic activity of the virus-encoded G-protein-coupled receptor.
|
22942256 |
2012 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.
|
21159881 |
2011 |
|
Kaposi Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings provide a compelling explanation for how the few tumor cells expressing vGPCR can contribute to the dramatic amplification of VEGF secretion in KS, and further provide a molecular mechanism for how cytokine dysregulation in KS fuels angiogenesis and tumor development.
|
21559457 |
2011 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, this in vitro vGPCR-initiated signaling signature was observed in a large panel of human KS.
|
20818438 |
2011 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo.
|
19915163 |
2010 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor: Lessons on dysregulated angiogenesis from a viral oncogene.
|
20213674 |
2010 |
|
Kaposi Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Indeed, ANGPTL4 expression is a hallmark of vGPCR experimental and human KS lesions.
|
20660728 |
2010 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus K7 induces viral G protein-coupled receptor degradation and reduces its tumorigenicity.
|
18802460 |
2008 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
|
17329974 |
2007 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Its expression is up-regulated by the G protein-coupled receptor from the Kaposi sarcoma-associated herpes virus (vGPCR).
|
17881360 |
2007 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.
|
17483315 |
2007 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these results implicate mTOR in KS initiation and suggest that the sarcomagenic potential of KSHV may be a direct consequence of the profound sensitivity of endothelial cells to vGPCR dysregulation of the TSC2/mTOR pathway.
|
16904612 |
2006 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
If KS is indeed dependent on vGPCR dysregulation, then the development of new therapeutic modalities specifically targeting this viral protein or its downstream targets may ultimately prove to be the most effective treatment strategy for this enigmatic disease.
|
15003988 |
2004 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR.
|
12620408 |
2003 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor constitutively activates NF-kappa B and induces proinflammatory cytokine and chemokine production via a C-terminal signaling determinant.
|
11418689 |
2001 |
|
Kaposi Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor monocistronic and bicistronic transcripts in primary effusion lymphomas.
|
11504542 |
2001 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B.
|
11289142 |
2001 |
|
Kaposi Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
While vCYC (AKS 6 of 6; CKS 3 of 3), vMIP-I (AKS 5 of 6, CKS 3 of 3), vBCL2 (AKS 6 of 6; CKS 3 of 3), and vIRF1 (AKS 5 of 6, CKS 3 of 3) transcripts were detected in both AKS and CKS, vGCR and HIV-1 Tat were expressed only in AKS samples (vGCR: AKS 3 of 6, CKS 0 of 3; Tat: AKS 4 of 6, CKS 0 of 3). vMIPII, vCBP, and vIL6 expression were not detected in any KS samples.
|
10662620 |
2000 |
|
Kaposi Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of the open reading frame 74 (G-protein-coupled receptor) gene of Kaposi's sarcoma (KS)-associated herpesvirus: implications for KS pathogenesis.
|
10364352 |
1999 |
|
Kaposi Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Point mutation causing constitutive signaling of CXCR2 leads to transforming activity similar to Kaposi's sarcoma herpesvirus-G protein-coupled receptor.
|
10438939 |
1999 |