|
Mitral Valve Prolapse Syndrome
|
0.110 |
Biomarker
|
disease |
BEFREE |
In combination with previously available data, we now report a genome-wide significant association with MVP (odds ratio, 1.20; P=4.36×10<sup>-10</sup>), indicating that Glis1 is expressed during embryonic development predominantly in nuclei of endothelial and interstitial cells of mitral valves in mouse.
|
31112420 |
2019 |
|
Mitral Valve Prolapse Syndrome
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genetic association analyses highlight biological pathways underlying mitral valve prolapse.
|
26301497 |
2015 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
This review provides a short overview of the critical roles genetic changes in GLIS1-3 play in the development of several malignancies.
|
31474360 |
2019 |
|
Acute Megakaryocytic Leukemias
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This includes intrachromosomal translocations involving GLIS2 and ETO2/CBFA2T3 in the development of pediatric non-Down's syndrome (DS), acute megakaryoblastic leukemia (AMKL), a malignancy with poor prognosis, and an association of interchromosomal translocations between GLIS3, GLIS1, and PAX8, and between GLIS3 and CLPTM1L with hyalinizing trabecular tumors (HTTs) and fibrolamellar hepatocellular carcinoma (FHCC), respectively.
|
31474360 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The hyalinizing trabecular adenoma/tumor is a rare and poorly characterized follicular-derived thyroid neoplasm recently shown to harbor recurrent PAX8-GLIS1 or PAX8-GLIS3 gene fusions.
|
31273314 |
2019 |
|
Fibrolamellar Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This includes intrachromosomal translocations involving GLIS2 and ETO2/CBFA2T3 in the development of pediatric non-Down's syndrome (DS), acute megakaryoblastic leukemia (AMKL), a malignancy with poor prognosis, and an association of interchromosomal translocations between GLIS3, GLIS1, and PAX8, and between GLIS3 and CLPTM1L with hyalinizing trabecular tumors (HTTs) and fibrolamellar hepatocellular carcinoma (FHCC), respectively.
|
31474360 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
GLI-similar 1-3 (GLIS1-3), a subfamily of Krüppel-like zinc finger transcription factors, function as key regulators of several biological processes important to oncogenesis, including control of cell proliferation, differentiation, self-renewal, and epithelial-mesenchymal transition.
|
31474360 |
2019 |
|
Thyroid Hyalinizing Trabecular Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further analysis identified PAX8-GLIS3 in 13/14 (93%) and PAX8-GLIS1 in 1/14 (7%) of HTT confirmed after blind pathology review.
|
30648929 |
2019 |
|
Regurgitation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We also show that Glis1 knockdown causes atrioventricular regurgitation in developing hearts in zebrafish.
|
31112420 |
2019 |
|
Venezuelan equine encephalomyelitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We previously generated induced tissue-specific stem cells from mouse pancreatic cells using a single synthetic self-replicating Venezuelan Equine Encephalitis (VEE)-reprogramming factor (RF) RNA replicon (SR-RNA) expressing the reprogramming factors POU class 5 homeobox 1 (OCT4), Krueppel-like factor 4 (KLF4), Sex determining region Y-box 2 (SOX2), and Glis Family Zinc Finger 1 (GLIS1).
|
30404192 |
2018 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two novel loci associated with Aβ<sub>42</sub> near GLIS1 on 1p32.3 (β = -0.059, P = 2.08 × 10<sup>-8</sup>) and within SERPINB1 on 6p25 (β = -0.025, P = 1.72 × 10<sup>-8</sup>) were also associated with AD risk (GLIS1: OR = 1.105, P = 3.43 × 10<sup>-2</sup>), disease progression (GLIS1: β = 0.277, P = 1.92 × 10<sup>-2</sup>), and age at onset (SERPINB1: β = 0.043, P = 4.62 × 10<sup>-3</sup>).
|
28247064 |
2017 |
|
Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphism (SNP) rs797906 of the GLIS family zinc finger 1 (GLIS1) gene has been linked to a risk of Parkinson's disease (PD) in genome-wide association studies of Caucasian populations.
|
22759478 |
2012 |
|
PARKINSON DISEASE, LATE-ONSET
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GLIS1 rs797906: an increased risk factor for late-onset Parkinson's disease in the Han Chinese population.
|
22759478 |
2012 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A similar induction of Glis1 mRNA by PMA treatment was observed in the immortalized epidermal keratinocyte cell line NHEK-HPV, whereas PMA did not induce Glis1 in HaCaT cells or in several squamous cell carcinoma cell lines.
|
16417217 |
2006 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Glis1 mRNA is not expressed in normal human epidermis, but is significantly induced in psoriatic epidermis and in mouse skin upon treatment with the tumor promoter phorbol-12-myristate-13-acetate (PMA).
|
16417217 |
2006 |
|
Psoriasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This, in association with its induction in psoriasis, suggests that transcriptional factor Glis1 is involved in the regulation of aberrant differentiation observed in psoriatic epidermis.
|
16417217 |
2006 |