CTH, cystathionine gamma-lyase, 1491

N. diseases: 93; N. variants: 5
Disease: Cardiovascular Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.040 Biomarker group BEFREE The cystathionine γ-lyase/hydrogen sulfide (CSE/H<sub>2</sub>S) pathway have been associated with several cardiovascular diseases, but the effect of TFR on the Rho-associated protein kinase (ROCK) and CSE/H<sub>2</sub>S signaling pathways remains unknown. 31611932 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.040 GeneticVariation group BEFREE We also performed SNP analysis of H<sub>2</sub>S synthesizing enzymes and found a significant increase in cystathionine gamma-lyase (CTH) 1364 G-T allele frequency in patients with CVD compared to controls. 29413960 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.040 AlteredExpression group BEFREE However, the molecular mechanisms that control CSEγ gene expression in the endothelium during cardiovascular diseases are unclear. 28188215 2017
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.040 Biomarker group BEFREE Mounting evidence demonstrated deficient cystathionine-γ-lyase (CSE)/H<sub>2</sub>S implicated the development of cardiovascular disease. 28669627 2017