Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Pooled OR and 95% CI was used to assess the association between the allelic, dominant and recessive models of IL23R rs11209026 and rs10889677 polymorphisms and UC and CD risk.
|
31728561 |
2020 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals.
|
30500874 |
2019 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Expansion of apoptosis-resistant intestinal TNFR2+IL23R+ T cells is associated with resistance to anti-TNF therapy in Crohn's disease.
|
29848778 |
2019 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> The interleukin 23 receptor gene (<i>IL23R</i>) is strongly associated with Crohn's disease (CD).
|
31799225 |
2019 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Specifically the G149R, V362I, and R381Q IL23Rα chain variants are linked to protection against the development of Crohn disease and ulcerative colitis in humans.
|
26887945 |
2016 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, a functional single nucleotide polymorphism (SNP) in the IL-23 receptor gene (IL-23R; rs11209026, 1142 G wild-type A reduced function, Arg381Gln, rs11209026" genes_norm="149233">R381Q) seems to confer a measure of protection against development of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis), ankylosing spondylitis, rheumatoid arthritis, psoriasis, thyroiditis, recurrent spontaneous abortion and asthma, suggesting that a perturbation in the IL-23 signaling pathway is likely to be relevant to the pathophysiology of these diseases.
|
27043356 |
2016 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
NOD2 p.L1007insC was associated with OFG+CD (P = 0.023) and IL23R p.R381Q with all OFG (P = 0.031).
|
27306066 |
2016 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results confirmed a significant association of CD with the following previously reported risk loci: rs3810936 in TNFSF15 (OR=1.83, p<2.2×10(-16)), rs76418789 in IL23R (OR=0.47, p=1.14×10(-8)) and rs2241880 in ATG16L1 (OR=1.30, p=5.28×10(-6)).
|
25731871 |
2016 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
A genome-wide association scan in Crohn's (CD) disease highlighted the interleukin-23 receptor (IL23R) gene as a susceptibility factor.
|
25858864 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Additional suggestive associations (P < 4.2 × 10(-5)) were observed between Crohn's disease and IBD and African-specific SNPs in STAT5A and STAT3; between IBD and SNPs in IL23R, IL12B, and C2orf43; and between ulcerative colitis and SNPs near HDAC11 and near LINC00994.
|
26278503 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ATG16L1 and IL23R variants and genetic susceptibility to crohn's disease: mode of inheritance based on meta-analysis of genetic association studies.
|
25738374 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The present study, using personal genomics analysis of a small CD pedigree, is the first to show that the low-frequency non-synonymous variant of IL23R, rs76418789, protects against CD development in Japanese subjects.
|
26375822 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These findings show that IL-23R genes confer susceptibility to CD in the Caucasians.
|
26090488 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Most notably, polymorphisms in the interleukin (IL)-23 receptor have also been linked to IBD - both CD and ulcerative colitis.
|
25523553 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Three haplotype blocks were identified across the 10 IL23R SNPs conferring different risk of CD.
|
24989722 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Thus, a meta-analysis was carried out to assess the association between the IL-23R polymorphisms and CD.
|
26678098 |
2015 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
For IL23R, all three SNPs were found not to be associated with the development of CD.
|
25048429 |
2014 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
After Bonferroni correction for multiple testing, both the homozygous and the heterozygous variant genotypes of IL23R G>A(rs11209026) (OR(CD,adj): 0.38, 95% CI: 0.21-0.67, p = 0.03; OR(IBD,adj) 0.43, 95% CI: 0.28-0.67, p = 0.007) and PTPN22 1858 G>A(rs2476601) (OR(CD,unadj) 0.54, 95% CI: 0.41-0.72, p = 7*10-4; OR(IBD,unadj): 0.61, 95% CI: 0.48-0.77, p = 0.001) were associated with reduced risk of CD.
|
24971461 |
2014 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
|
23850713 |
2014 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We observed the association between Crohn's disease and NOD2 (rs17313265, 0.28 in CD, 0.19 in controls, OR 1.5, p = 9×10-6) and IL23R (rs11209026, 0.026 in CD, 0.0.071 in controls, OR 0.4, p = 3.8×10-4).
|
25259511 |
2014 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this Algerian cohort, NOD2/CARD15 and IL23R variants were associated with CD's outcomes and linked to a particular clinical phenotype.
|
24679666 |
2014 |