IL23R, interleukin 23 receptor, 149233

N. diseases: 306; N. variants: 49
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. 23850713 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Genome wide association studies showed a highly significant association between interleukin 23 receptor (IL23R) single nucleotide polymorphisms (SNPs) and Crohn's disease; however, there are contrary results regarding the disease-modifying effects of IL23R variants in UC. 24485526 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE In general, genes encoding cytokines are genetically polymorphic and polymorphisms in genes IL23R el IL17F were shown associated with susceptibility to Crohn's disease and ulcerative colitis which in their turn are considered as risk factors for developing colorectal cancer (CRC). 24440568 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. 22936669 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Serological analysis consisted of a seven antibody panel, and DNA was tested for CD-associated NOD2 variants (rs2066845,rs2076756,rs2066847), ATG16L1 (rs3828309, rs2241880) and IL23R (rs11465804). 23725363 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Moreover, genome-wide association studies have revealed that variants of the gene encoding the IL-23 receptor, as well as the locus harboring the gene encoding the p40 chain, confer genetic risk for developing Crohn's disease (CD) and ulcerative colitis (UC). 24138637 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE IL-22 expression-modulating, CD risk-associated IL23R variants influence DMBT1 expression in CD patients and DMBT1 levels are increased in the inflamed intestinal mucosa of CD patients. 24223725 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis. 23093364 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 AlteredExpression disease BEFREE Additionally, the mRNA and protein expression of JAK2 and IL-23R were increased in UC and Crohn's disease (CD) patients. 24382939 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASCAT A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. 22936669 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis. 23054009 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASCAT 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. 22293688 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population. 22426692 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE DNA was tested for three CD-associated NOD2 variants (3020insC, G908R, R702W), variants in IRGM, ATG16L1, IL12B, IL23R, STAT3, and a TLR5-stop mutation. 22275320 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE CD was associated with NOD2 carrier (6.93% CD, 2.15% Controls, P = 0.007), ATG16L1 Thr300Ala (36.1% CD, 29.3% Controls, P = 0.003), SLC22A4 and SLC22A5 (IBD5 locus) functional SNPs (Leu503Phe [10.5% CD, 7.6% Controls, P = 0.05] and g-207c [41.3% CD, 35.7% Controls, P = 0.03], respectively), and IL23R rs2201841 (18.2% CD, 13.8% Controls, P = 0.03), but not IRGM variants, nor three African ancestral NOD2 nonsynonymous variants.IBD5 risk was recessive. 22411504 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE There is a strong association between both IBD5 locus variants but not the IL23R gene variant with CD in the Malaysian population. 22908971 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE IL-23R gene variants have been identified as risk factors for two major inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, but how they contribute to disease is poorly understood. 22262659 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease BEFREE We found strong evidence of CD-association for 195 genes, identifying novel susceptibility genes (e.g., ISX, SLCO6A1, TMEM183A) as well as confirming many previously identified susceptibility genes in CD GWAS (e.g., IL23R, NOD2, CYLD, NKX2-3, IL12RB2, ATG16L1). 23071489 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 AlteredExpression disease BEFREE The Th17 phenotype has been linked to CD by the fact that IL-22, IL-17 and IL-23 receptor levels are increased in CD. 22664939 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE One is SNP rs11209026 in exon 9 of IL23R for association with Crohn's disease, which is predicted to be probably damaging by PolyPhen2. 22293688 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASCAT A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. 22412388 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease BEFREE Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis. 22346247 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Interleukin (IL)-23R was associated with CD in South Koreans (OR 1.8; 95% CI 1.16-2.82) and a single nucleotide polymorphism in IL-23R (Gly149Arg) was protective of CD in Han Chinese (OR 0.3; 95% CI 0.15-0.60). 21887729 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Interleukin-23 is involved in pro-inflammatory signaling; genetic variation in the interleukin-23 receptor (IL23R) has been consistently associated with CD and UC risk. 22154103 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. 22293688 2012