IL23R, interleukin 23 receptor, 149233

N. diseases: 306; N. variants: 49
Disease: Colitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009319
Disease: Colitis
Colitis 		0.050 Biomarker disease BEFREE In contrast to DSS-induced colitis, defects in IL-12R and IL-23R both protect from the spontaneous colitis observed in IL10<sup>-/-</sup> mice. 31158699 2019
CUI: C0009319
Disease: Colitis
Colitis 		0.050 Biomarker disease BEFREE IL-23R blockade prevented progression to colitis, whereas nTreg cell transfers prevented colitic disease, ileal crypt hyperplasia and ileal-reactive Treg accumulation. 29728642 2018
CUI: C0009319
Disease: Colitis
Colitis 		0.050 Biomarker disease BEFREE Loss-of-function variants of the IL23-receptor gene (IL23R) protect against IBD, and, in animals, blocking IL23 reduces the severity of colitis. 27780712 2017
CUI: C0009319
Disease: Colitis
Colitis 		0.050 Biomarker disease BEFREE Colitis-associated Batf(-/-) tumours lacked IL-17a(+)IL-23R(+)IL-6(+)CD4(+) T cells, hence displaying characteristics reminiscent of human CRC-infiltrating CD4(+) T cells. 25838550 2016
CUI: C0009319
Disease: Colitis
Colitis 		0.050 GeneticVariation disease BEFREE Here we investigate the consequence of IL-23R deletion in dextran sulfate sodium (DSS)-induced colitis. 22089030 2012