|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Pooled OR and 95% CI was used to assess the association between the allelic, dominant and recessive models of IL23R rs11209026 and rs10889677 polymorphisms and UC and CD risk.
|
31728561 |
2020 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Pooled OR and 95% CI was used to assess the association between the allelic, dominant and recessive models of IL23R rs11209026 and rs10889677 polymorphisms and UC and CD risk.
|
31728561 |
2020 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Th17 T<sub>EM</sub> cells (expressing <i>IL17A, IL17F, RORC</i>, and <i>STAT3</i>) displayed a higher pathogenic/cytotoxic (<i>IL23R, IL18RAP</i>, and <i>GZMB, CD160, PRF1</i>) gene signature in CD relative to UC, while non-pathogenic/regulatory genes (<i>IL9, FOXP3, CTLA4</i>) were more elevated in UC.
|
31191543 |
2019 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals.
|
30500874 |
2019 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Expansion of apoptosis-resistant intestinal TNFR2+IL23R+ T cells is associated with resistance to anti-TNF therapy in Crohn's disease.
|
29848778 |
2019 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> The interleukin 23 receptor gene (<i>IL23R</i>) is strongly associated with Crohn's disease (CD).
|
31799225 |
2019 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to determine whether the IL-23R polymorphisms confer susceptibility to UC.
|
27902482 |
2017 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, 9 genes previously associated with IBD contained SNPs with significant evidence for replication (P < 1.6 × 10<sup>-6</sup>): ADCY3, CXCR6, HLA-DRB1 to HLA-DQA1 (genome-wide significance on conditioning), IL12B,PTGER4, and TNC for IBD; IL23R, PTGER4, and SNX20 (in strong linkage disequilibrium with NOD2) for CD; and KCNQ2 (near TNFRSF6B) for UC.
|
27693347 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The association of genes in the epithelial barrier and the Th17-IL23R pathways were similar in the Japanese and European UC populations.
|
26511940 |
2016 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans.
|
26398853 |
2016 |
|
Ulcerative Colitis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Our study suggests that even after an established role of VA in inhibiting Th17 responses in mice models and humans, serum VA levels and disease activity do not correlate with FOXP3 and IL-23R expression in colonic mucosa of UC patients.
|
27178149 |
2016 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10).
|
26398853 |
2016 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Specifically the G149R, V362I, and R381Q IL23Rα chain variants are linked to protection against the development of Crohn disease and ulcerative colitis in humans.
|
26887945 |
2016 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Specifically the G149R, V362I, and R381Q IL23Rα chain variants are linked to protection against the development of Crohn disease and ulcerative colitis in humans.
|
26887945 |
2016 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, a functional single nucleotide polymorphism (SNP) in the IL-23 receptor gene (IL-23R; rs11209026, 1142 G wild-type A reduced function, Arg381Gln, rs11209026" genes_norm="149233">R381Q) seems to confer a measure of protection against development of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis), ankylosing spondylitis, rheumatoid arthritis, psoriasis, thyroiditis, recurrent spontaneous abortion and asthma, suggesting that a perturbation in the IL-23 signaling pathway is likely to be relevant to the pathophysiology of these diseases.
|
27043356 |
2016 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
NOD2 p.L1007insC was associated with OFG+CD (P = 0.023) and IL23R p.R381Q with all OFG (P = 0.031).
|
27306066 |
2016 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results confirmed a significant association of CD with the following previously reported risk loci: rs3810936 in TNFSF15 (OR=1.83, p<2.2×10(-16)), rs76418789 in IL23R (OR=0.47, p=1.14×10(-8)) and rs2241880 in ATG16L1 (OR=1.30, p=5.28×10(-6)).
|
25731871 |
2016 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Most notably, polymorphisms in the interleukin (IL)-23 receptor have also been linked to IBD - both CD and ulcerative colitis.
|
25523553 |
2015 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In stratification analysis by ethnicity, we observed that the rs11209026 and rs7517847 polymorphism of IL-23R could protect against development of UC among Caucasian populations [rs11209026: dominant model (P=0.01, OR=0.69, 95%CI: 0.52-0.92); rs7517847: GG vs. TT (P=0.002, OR=0.69, 95%CI: 0.54-0.87); recessive model (P=0.004, OR=0.73, 95% CI: 0.59-0.90)]; the rs11209032 were associated with a greater risk for UC in Caucasian populations [dominant model (P=0.04, OR=1.13, 95%CI: 1.00-1.26)]; the rs1088967 were associated with a lower risk for UC among Asian populations [dominant model (P=0.04, OR=0.73, 95%CI: 0.54-0.99)].
|
25497273 |
2015 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |