|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As a member of the p120-catenin (p120ctn) subfamily, the p0071 study in tumor is very limited.
|
28898462 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumors with low P120CTN and PI3K pathway mutations have higher levels of MMP1 compared to tumors with high P120CTN and no PI3K pathway mutations.
|
28637905 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous studies have shown that dietary calcium suppresses oral carcinogenesis, but the mechanism is unclear. p120-catenin (p120) is a cytoplasmic protein closely associated with E-cadherin to form the E-cadherin-β-catenin complex and may function as a tumor suppressor in the oral epithelium.
|
27682597 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia.
|
29130932 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study provides evidence that CTNND1 functions as a novel tumor oncogene in HCC, and may be a potential therapeutic target for HCC management.
|
27193094 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mice with biallelic loss of p120 catenin progressively develop high-grade pancreatic intraepithelial neoplasia (PanIN) lesions and neoplasia accompanied by prominent acute and chronic inflammatory processes, which is mediated, in part, through NF-κB signaling.
|
27032419 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Increasing evidence supports the association of catenin-δ1 (CTNND1, p120ctn) with tumour development and progression.
|
25470111 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We applied this method to more than 4000 samples from the The Cancer Genome Atlas project to obtain novel splicing signatures that are predictive for nine different cancer types, and find a specific signature for basal-like breast tumors involving the tumor-driver CTNND1.
|
25578962 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The immunohistochemical expression of α-, β- and p120-catenin was studied in a series of normal feline mammary glands, hyperplastic/dysplastic lesions and benign and malignant mammary tumors.
|
26026096 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism driving tumor growth and metastasis.
|
25713299 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The CAS/imp-α1 transport cycle is linked to XIAP and is required to maintain tumor cell survival in HCC.
|
24799195 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, indirect inactivation of the adherens junction through conditional knockout of p120 in mice was recently linked to tumor formation, indicating that p120 can also function as a tumor suppressor.
|
23950111 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We report herein that p120ctn loss leads to tumor development in mice.
|
21481789 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We detected changes in 'boundary cells' within histological sections of human squamous cell carcinomas that were similar to those observed in Drosophila: both E-cadherin and p120-catenin exhibited normal junctional localization at the centers of the tumors but were reduced or delocalized at the boundary.
|
20363916 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cytoplasmic p120ctn isoform 1 expression in metastatic nodules was always higher than in the primary tumor.
|
19763914 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors.
|
20470445 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, reduced expression of P120 catenin mRNA and protein in tumour correlated with a worse prognosis and normal expression with a better survival rate (P=0.022, P=0.007).
|
19754472 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accumulating evidences indicate that p120-catenin is important in tumour formation and progression, although the role of their multiple spliced isoforms in the regulation of cadherin-mediated adhesion of malignant cells is still not well understood.
|
18032823 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On loss of E-cadherin, cytoplasmic p120ctn might accumulate and contribute to tumor malignancy.
|
17047063 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Of note, we observed that 53% of tumors presented cytoplasmic staining for p120ctn, and statistical analysis revealed that this localization is predictive of poor patient outcome.
|
16322241 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer.
|
12671892 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120.
|
14610055 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Potential roles of p120 as a tumor suppressor or metastasis promoter are discussed.
|
12492499 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of betaglycan and p120 in most GCT argues against the hypothesis, but does not exclude the possibility that low or absent expression of p120 might be significant in a subset of these tumors.
|
11889215 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, CAS/Crk assembly serves as a "molecular switch" for the induction of cell migration and appears to contribute to the invasive property of tumors.
|
9472046 |
1998 |