PLB1, phospholipase B1, 151056

N. diseases: 219; N. variants: 10
Disease: Depressed mood ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.020 Biomarker phenotype BEFREE Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels. 20034614 2010
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.020 Biomarker phenotype BEFREE Specifically it is hypothesized that having genetically determined low activity of fatty acid CoA ligase 4 and/or Type IV phospholipase A(2) combined with the low dietary availability of omega-3 PUFA results in reduced cellular uptake of omega-3 PUFA and constitutes a risk factor for depression. 17045757 2007