CYBB, cytochrome b-245 beta chain, 1536

N. diseases: 343; N. variants: 75
Disease: Encephalomyelitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.030 GeneticVariation disease BEFREE Nox2 deletion prevented EAE-induced induction of pro-inflammatory cytokines and stimulated the expression of the anti-inflammatory cytokines IL-4 and IL-10. 30984416 2019
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.030 AlteredExpression disease BEFREE Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression. 30151738 2018
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.030 AlteredExpression disease BEFREE Active lesions in the marmoset EAE brain display increased expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (p22phox, p47phox, and gp91phox) and inducible nitric oxide synthase immunoreactivity within lesions with active inflammation and demyelination, coinciding with enhanced expression of mitochondrial heat-shock protein 70 and superoxide dismutase 1 and 2. 28505283 2017