Disease: Lung Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.320 AlteredExpression group BEFREE Modulation of CYP1A1/CYP1A2 levels markedly reduced parent drug concentrations, significantly altering metabolite pharmacokinetics (PK) in humanized mice <i>in vivo</i><b>Conclusions:</b> We demonstrate that a P450 enzyme expressed in smokers' lungs and lung tumors has the capacity to metabolise osimertinib. 29437786 2018
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.320 Biomarker group CTD_human Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men. 22072123 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.320 GeneticVariation group LHGDN NAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status. 17477782 2007