|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Trp64Arg polymorphism in the beta(3)-adrenoceptor gene has been associated with increased prevalence of obesity, type 2 diabetes, and low rates of energy expenditure, although these findings are not unanimous.
|
12037740 |
2002 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that in obese women the beta 3-AR polymorphism may be used as a genetic marker for visceral fat obesity and the insulin resistance syndrome.
|
9049481 |
1997 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Trp64Arg polymorphism of ADRB3 seems to not be related to obesity in postmenopausal women.
|
17852419 |
2007 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study we investigated the prevalence of the two beta 3-AR alleles in a Caucasian population and studied the association between the beta 3-AR genotype and metabolic disorders (obesity and type 2 diabetes).
|
11213599 |
2001 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
To determine if common single nucleotide polymorphisms (SNPs) in beta(1)-adrenergic receptor (ADRB1), beta(2)-adrenergic receptor (ADRB2), beta(3)-adrenergic receptor (ADRB3), and alpha(2)-adrenergic receptor (ADRA2A) genes associate with obesity and metabolic alterations, we recruited 74 healthy African American and 161 white men and women (age, 18-49 years) to participate in this case-control genetic association study.
|
17512307 |
2007 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results indicated that the ADRB3 Trp64Arg variant is not related to the development of GDM and has no effect on obesity during pregnancy in a Taiwanese population.
|
15334374 |
2004 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the Trp64Arg mutation in its heterozygous form is not a major determinant of beta 3-adrenergic receptor function (when assessed by lipolysis in white adipose tissue) or of the pathophysiology of obesity.
|
8817112 |
1996 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, the incidence of a naturally occurring variant of the human beta 3-adrenergic receptor was shown to correlate with hereditary obesity in Pima Indians and Japanese individuals.
|
10714358 |
2000 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.
|
18335327 |
2008 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether mutations in the gene for the beta 3-adrenergic receptor predispose patients to obesity and non-insulin-dependent diabetes mellitus (NIDDM), we studied this gene in 10 Pima Indians by analysis of single-stranded conformational polymorphisms and dideoxy sequence analysis.
|
7609750 |
1995 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using both parametric and nonparametric methods, we found no evidence of linkage of obesity to any of nine candidate genes/regions, including the Prader-Willi chromosomal region (PWS), the human homologue of the mouse agouti gene (ASP), and the genes for leptin (OB), the leptin receptor (OBR/DB), the beta3-adrenergic receptor (ADRB3), lipoprotein lipase (LPL), hepatic lipase (LIPC), glycogen synthase (GYS), and tumor necrosis factor alpha (TNFA).
|
9326333 |
1997 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A study on the genetics of obesity: influence of polymorphisms of the beta-3-adrenergic receptor and insulin receptor substrate 1 in relation to weight loss, waist to hip ratio and frequencies of common cardiovascular risk factors.
|
10826514 |
2000 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that epigenetic changes in the ADRB3 gene locus may explain the development of obesity and non-communicable diseases associated with trans-fat intake, altered lipid profile, and elevated folic acid.
|
30954083 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
UCP1 -3826A/G and ADRB3 Trp64Arg polymorphisms may have a combined effect in the modulation of overweight/obesity and HDL-C levels in type 2 diabetes mellitus (T2DM) Caucasian-Brazilian patients.
|
24138564 |
2014 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
TRP64ARG beta 3-adrenergic receptor and obesity in Mexican Americans.
|
9439659 |
1997 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To further elucidate the role of these genes in the pathophysiology of obesity the present study investigated associations between certain polymorphisms in ADRB2 and ADRB3 and parameters of carbohydrate and lipid metabolism in a population of African origin.
|
18393130 |
2008 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Collectively, we demonstrated that inflammatory response to obesity, such as TLR4 and NLRP3 inflammasome activation as well as IL-1β secretion, attenuates β3-adrenoreceptor-induced beige adipocyte formation via oxidative stress and mitochondrial dysfunction.
|
29264745 |
2018 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study examined the possible association of the β3-AR and UCP1 polymorphisms with overweight/obesity or lipid variation in a Southwest Chinese population.
|
25928572 |
2015 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The variants of the causal genes were selected based on their functions, including: obesity (adrenergic, beta-3-, receptor: ADRB3), alcohol consumption (aldehyde dehydrogenase 2: ALDH2), water-electrolyte metabolism (guanine nucleotide binding protein [G protein], beta polypeptide 3: GNB3), glycometabolism (peroxisome proliferator-activated receptor gamma: PPARG), lipometabolism (cholesteryl ester transfer protein, plasma: CETP), atherosclerosis (5,10-methylenetetrahydrofolate reductase [NADPH]: MTHFR), and cellular behavior (gap junction protein, alpha 4, 37 kD: GJA4).
|
17785925 |
2007 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We suggest that the beta(3)-AR gene variant is not important as an obesity-inducing factor in Japanese.
|
11532330 |
2001 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thus, the interference of the ADRB3 pathway in adipocytes may provide a potential treatment target for obesity.
|
30580338 |
2018 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort.
|
9709965 |
1998 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Beta 3-adrenergic receptor gene polymorphism is not a major genetic determinant of obesity and diabetes in Japanese general population.
|
9279471 |
1997 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Some variants of the ADRB3 gene may predispose subjects for the development obesity and metabolic abnormalities in the setting of modern sedentary lifestyle.
|
21992420 |
2011 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To estimate the frequency of Arg64 allele of the beta(3)-adrenergic receptor (3-BAR) gene in healthy (H) and obese (O) Hungarian children, and to look for possible associations between this polymorphism and some clinical and metabolic characteristics of obese children.
|
15942638 |
2005 |