|
Obesity
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Obesity
|
0.500 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether mutations in the gene for the beta 3-adrenergic receptor predispose patients to obesity and non-insulin-dependent diabetes mellitus (NIDDM), we studied this gene in 10 Pima Indians by analysis of single-stranded conformational polymorphisms and dideoxy sequence analysis.
|
7609750 |
1995 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Trp64Arg allele of the beta 3-adrenergic receptor is associated with abdominal obesity and resistance to insulin and may contribute to the early onset of NIDDM:
|
7609751 |
1995 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A mutation in the beta 3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects.
|
7487991 |
1995 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the Trp64Arg mutation in its heterozygous form is not a major determinant of beta 3-adrenergic receptor function (when assessed by lipolysis in white adipose tissue) or of the pathophysiology of obesity.
|
8817112 |
1996 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent molecular screening and analysis of a common missense mutation of the beta 3-adrenergic receptor gene suggested this locus as a strong candidate for increased obesity, earlier age of diabetes onset, and insulin resistance.
|
8954053 |
1996 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These findings do not support the view that there is an association between the Trp64Arg mutation in the ADRB3 gene and obesity.
|
8903328 |
1996 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Molecular scanning for mutations in the beta 3-adrenergic receptor gene in Nauruans with obesity and noninsulin-dependent diabetes mellitus.
|
8923875 |
1996 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
In conclusion, IRS-1 972 had an increased prevalence in subjects with insulin resistance, with or without dyslipidaemia. beta 3-AR 64 was associated with increased obesity but not with insulin resistance or dyslipidaemia.
|
8960833 |
1996 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that in young healthy Danes, the homozygous form but not the heterozygous form of the codon 64 amino acid polymorphism of the beta 3-adrenergic receptor may be associated with obesity and, independent of BMI, with a low SI.
|
8690160 |
1996 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that in obese women the beta 3-AR polymorphism may be used as a genetic marker for visceral fat obesity and the insulin resistance syndrome.
|
9049481 |
1997 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using both parametric and nonparametric methods, we found no evidence of linkage of obesity to any of nine candidate genes/regions, including the Prader-Willi chromosomal region (PWS), the human homologue of the mouse agouti gene (ASP), and the genes for leptin (OB), the leptin receptor (OBR/DB), the beta3-adrenergic receptor (ADRB3), lipoprotein lipase (LPL), hepatic lipase (LIPC), glycogen synthase (GYS), and tumor necrosis factor alpha (TNFA).
|
9326333 |
1997 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
TRP64ARG beta 3-adrenergic receptor and obesity in Mexican Americans.
|
9439659 |
1997 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Beta 3-adrenergic receptor gene polymorphism is not a major genetic determinant of obesity and diabetes in Japanese general population.
|
9279471 |
1997 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between the Trp64 Arg mutation in the beta 3-adrenergic receptor gene and obesity in Japanese men: a longitudinal analysis.
|
9100608 |
1997 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort.
|
9709965 |
1998 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This suggests that the ADRB3 R64 allele is probably not a major determinant of obesity or NIDDM in these aboriginal Canadians.
|
9589254 |
1998 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans.
|
9449691 |
1998 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Heterozygosity for the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not accompanied by obesity, impaired glucose tolerance and type 2 diabetes mellitus in the general elderly Dutch population, and is also not associated with changes in circulating leptin levels.
|
9828912 |
1998 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, the incidence of a naturally occurring variant of the human beta 3-adrenergic receptor was shown to correlate with hereditary obesity in Pima Indians and Japanese individuals.
|
10714358 |
2000 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A study on the genetics of obesity: influence of polymorphisms of the beta-3-adrenergic receptor and insulin receptor substrate 1 in relation to weight loss, waist to hip ratio and frequencies of common cardiovascular risk factors.
|
10826514 |
2000 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mice expressing alpha 2-ARs in fat, in the absence of beta 3-ARs (beta 3-AR -/- background), developed high fat diet-induced obesity.
|
10948198 |
2000 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study we investigated the prevalence of the two beta 3-AR alleles in a Caucasian population and studied the association between the beta 3-AR genotype and metabolic disorders (obesity and type 2 diabetes).
|
11213599 |
2001 |