|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Altogether, ADRB3 gene Trp64Arg mutation was significantly associated with an increased predisposition toward hypertension and elevated systolic/diastolic BP in hypertensive patients, suggesting that Trp64Arg is an important hypertension-susceptibility marker.
|
28404887 |
2017 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
These data reveal that ADRB3 in PVAT contributes to vascular function in the progression of hypertension.
|
26910302 |
2016 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association of PPAR-γ2 and β3-AR Polymorphisms With Postmenopausal Hypertension.
|
25827163 |
2015 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A missense mutation of the human ADRB3 gene replacing tryptophan with arginine at codon 64 (Trp64Arg) has been related to obesity, insulin resistance, earlier onset of noninsulin-dependent diabetes mellitus and hypertension.
|
18088254 |
2008 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, the prevalence of the Trp64Arg ADRB3 polymorphism in a large group of patients with OSAS and its association with body mass index (BMI), insulin resistance and hypertension were evaluated.
|
17626108 |
2007 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
LHGDN |
The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.
|
15824464 |
2004 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro.
|
12965109 |
2003 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, our data are compatible with a contribution of this genetic variant of ADRB3 to hypertension in male patients with type 2 diabetes.
|
10981554 |
2000 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We examined the association between mutations of the IRS-1 gene at codon 972, mutations of the beta-3-AR gene at codon 64, and the combination of both mutations with the degree of weight loss, waist to hip ratio and the prevalence of hypertension, dyslipidemia and type 2 diabetes mellitus.
|
10826514 |
2000 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results are consistent with the thesis that the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated more often with the condition of high blood pressure than with normal blood pressure.
|
10100091 |
1999 |