Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
Here we summarize the results of studies describing the associations between the UCP1 gene polymorphisms A-3826G, A-1766G, Met229Leu and Ala64Thr and polymorphism Trp64Arg in the β3-AR gene, their correlations and their associations with the occurrence of metabolic syndrome.
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28100847 |
2016 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
We investigated whether the -3826A/G polymorphism (rs1800592) of the uncoupling protein 1 gene (UCP1) and the rs4994" genes_norm="155">Trp64Arg polymorphism (rs4994) of the β3-adrenergic receptor gene (ADRB3) are associated with type 2 diabetes mellitus (T2DM) and features of metabolic syndrome in a Brazilian-Caucasian population.
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24138564 |
2014 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
Trp64Arg polymorphism of the ADRB3 gene may affect VF accumulation and be associated with MS, a cluster of conditions involving aggravated lipid metabolism and higher blood pressure, in Japanese children.
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23282015 |
2013 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
To study an association between Trp64Arg polymorphism of the ADRB3 and metabolic syndrome (MS) components in an ethnic Kyrgyz group.
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21992420 |
2011 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
The non-synonymous rs4994 polymorphism of the ADRB3 gene was associated with T2D (Trp allele, OR = 0.62, p = 0.001) and MS (Trp allele, OR = 0.74, p = 0.018).
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20503258 |
2010 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
Comparison of populations indicated that no matter with the β3-AR gene mutation or not, the prevalence of MS in obese subjects was significantly higher than normal weight subjects (χ(2) = 28.240 and χ(2) = 15.586, all P < 0.005).
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21034552 |
2010 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
The presence of the Glu27 and Arg64 polymorphisms of the ADRB2 and ADRB3 genes are not directly related to indices of the metabolic syndrome.
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18393130 |
2008 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
The aim of the present study was to evaluate the frequency of ADRB3 polymorphism and its association with metabolic syndrome in postmenopausal women.
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18335327 |
2008 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
Metabolic syndrome and ADRB3 gene polymorphism in severely obese patients from South Italy.
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17299491 |
2007 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
Multiple logistic regression analysis including smoking, sex, and age as confounding factors showed no interaction between MS and ADRB3 polymorphism (odds ratio: 0.94; 95% confidence interval: 0.59-1.49; p=0.78).
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17345789 |
2006 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro.
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12965109 |
2003 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
The Trp64Arg beta3AR variant is associated in some, but not all, studies with an earlier onset of Type 2 diabetes mellitus and features of the insulin resistance syndrome.
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10441039 |
1999 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
We conclude that in obese women the beta 3-AR polymorphism may be used as a genetic marker for visceral fat obesity and the insulin resistance syndrome.
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9049481 |
1997 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is unlikely to be a major genetic predisposer to NIDDM or insulin resistance syndrome in subjects from eastern Finland.
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9250462 |
1997 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
We recently identified a mutation in the human beta 3-adrenergic receptor (beta 3AR) gene (codon 64 TGGTrp -> CGGArg; TRP64ARG) that associates with features of the insulin resistance syndrome and an earlier onset of noninsulin-dependent diabetes mellitus (NIDDM).
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8923875 |
1996 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
We conclude that the beta 3-adrenergic receptor locus does not play an important role in NIDDM susceptibility or in the insulin resistance syndrome among members of families with a strong predisposition to NIDDM.
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8954053 |
1996 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
A possible pathogenic mutation in the beta 3-adrenergic-receptor gene (Trp64Arg) has been reported to be associated with an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and clinical features of the insulin resistance syndrome in Pima Indian, Finnish and French subjects.
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8721782 |
1996 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
In addition, since recent studies suggest the contribution of beta3 adrenergic receptor to the insulin resistance syndrome, the gene encoding beta3 adrenergic receptor (ADRB3) was also studied.
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9240761 |
1996 |
Metabolic Syndrome X
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0.100 |
GeneticVariation
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disease |
BEFREE |
Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns.
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7609751 |
1995 |