|
Congenital chromosomal disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
We evaluated chromosome aberrations (CAs) in lymphocytes of 200 workers exposed to organic solvents and 200 referents and the influence of polymorphisms in xenobiotic-metabolism (CYP2E1, GSTM1 and GSTT1) and in DNA repair genes (XRCC1(194) Arg/Trp, XRCC1(280) Arg/His, XRCC1(399) Arg/Gln and XRCC3(241) Thr/Met).
|
19481674 |
2009 |
|
Congenital chromosomal disease
|
0.070 |
Biomarker
|
group |
BEFREE |
The initial study found that urine concentrations of the metabolites 1,2-dihydroxy-4-(acetyl) butane (M1) and 1-dihydroxy-2-(N-acetylcysteinyl)-3-butene (M2) and blood concentrations of the hemoglobin adducts N-[2-hydroxy-3-butenyl] valine (HB-Val) and N-[2,3,4-trihydroxy-butyl] valine (THB-Val) constitute excellent biomarkers of exposure, both being highly correlated with BD exposure levels, and that GST genotypes modulate at least one metabolic pathway, but that irreversible genotoxic effects such as chromosome aberrations and HPRT gene mutations are neither associated with BD exposure levels nor with worker genotypes (GST [glutathione-S-transferase]-M1, GSTT1, CYP2E1 (5' promoter), CYP2E1 (intron 6), EH [epoxide hydrolase] 113, EH139, ADH [alcohol dehydrogenase]2 and ADH3).
|
16949064 |
2007 |
|
Congenital chromosomal disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
In the present study, we investigated markers of genotoxicity [chromosomal aberrations (CAs) and single-strand breaks (SSBs)] in a cohort of 110 tire plant workers engaged in jobs with different levels of xenobiotic exposure in relation to various polymorphisms in genes coding for biotransformation enzymes (CYP1A1, CYP2E1, EPHX1, GSTM1, GSTP1, and GSTT1) and in genes involved in DNA repair (XPD exon 23, XPG exon 15, XPC exon 15, XRCC1 exon 10, and XRCC3 exon 7).
|
15470755 |
2004 |
|
Congenital chromosomal disease
|
0.070 |
Biomarker
|
group |
BEFREE |
In this study, we examined the specificity of benzene-induced aneuploidy and the influence of genetic polymorphisms (GSTM1, GSTT1, GSTP1, NAT2, NQO1 and CYP2E1) on chromosomal aberrations.
|
15226677 |
2004 |
|
Congenital chromosomal disease
|
0.070 |
GeneticVariation
|
group |
BEFREE |
In addition, individuals who had inherited the CYP2E1(*)5B allele exhibited a significantly higher CA frequency (8.0 +/- 0.82) compared to those with the CYP2E1 wild-type genotype (4.31 +/- 0.35).
|
12355548 |
2002 |
|
Congenital chromosomal disease
|
0.070 |
AlteredExpression
|
group |
BEFREE |
The acquired data on single-strand breaks in DNA (SSBs), frequency of chromosomal aberrations and HPRT mutant frequency in peripheral blood lymphocytes were compared to the results on genotyping of some of the xenobiotic-metabolising enzymes (CYP1A1, CYP2E1, epoxide hydrolase and GSTM1, GSTP1 and GSTT1).
|
11535253 |
2001 |
|
Congenital chromosomal disease
|
0.070 |
Biomarker
|
group |
BEFREE |
Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes.
|
10803680 |
2000 |