|
Alcoholic Liver Diseases
|
0.300 |
Biomarker
|
group |
BEFREE |
One mechanism by which alcoholic liver disease (ALD) progresses is oxidative stress and the generation of reactive oxygen species, among others due to the induction of cytochrome P-4502E1 (CYP2E1).
|
29120493 |
2018 |
|
Alcoholic Liver Diseases
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Ethanol-mediated up-regulation of CYP2E1 via SUMOylation enhancing its protein stability and activity and may have important implications in ALD.-Tomasi, M. L., Ramani, K., Ryoo, M., Cossu, C., Floris, A., Murray, B. J., Iglesias-Ara, A., Spissu, Y., Mavila, N. SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease.
|
29401608 |
2018 |
|
Alcoholic Liver Diseases
|
0.300 |
Therapeutic
|
group |
RGD |
Aplysin Protects Against Alcohol-Induced Liver Injury Via Alleviating Oxidative Damage and Modulating Endogenous Apoptosis-Related Genes Expression in Rats.
|
30192013 |
2018 |
|
Alcoholic Liver Diseases
|
0.300 |
Biomarker
|
group |
BEFREE |
Alcoholic Liver Disease: from CYP2E1 to CYP2A5.
|
26278389 |
2017 |
|
Alcoholic Liver Diseases
|
0.300 |
Biomarker
|
group |
BEFREE |
Targeting the JNK pathway or its downstream effectors may be a useful therapeutic approach to the oxidative stress generated by CYP2E1 in alcoholic liver disease.
|
25462060 |
2014 |
|
Alcoholic Liver Diseases
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Previous studies investigating the association between cytochrome P4502E1 (CYP2E1) polymorphisms and the risk of alcoholic liver diseases (ALD) have yielded conflicting results.
|
23335995 |
2013 |
|
Alcoholic Liver Diseases
|
0.300 |
AlteredExpression
|
group |
BEFREE |
These results provide in vivo evidence that CYP2E1 overexpression aggravates hepatic injury, and suggest that expression of cytokeratins 8 and 18 can be considered as biomakers for the progression of alcoholic liver disease.
|
19157621 |
2009 |
|
Alcoholic Liver Diseases
|
0.300 |
Biomarker
|
group |
BEFREE |
Oxidative and nitrosative stress are key to the pathogenesis of alcoholic liver disease, and there is now greater emphasis than previously on their development and role of cytochrome P450 2E1, on mitochondrial stress and disruption, (including elucidation of mitochondrial protection mechanisms) disturbance of signaling pathways and involvement of extrahepatic mediators like adiponectin.
|
18408461 |
2008 |
|
Alcoholic Liver Diseases
|
0.300 |
Biomarker
|
group |
LHGDN |
Accordingly, CYP2E1 priming could explain the sensitization of Kupffer cells to LPS activation by ethanol, a critical early step in alcoholic liver disease.
|
15961886 |
2005 |
|
Alcoholic Liver Diseases
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Ala substitution of Glu-248 and Lys-251 as well as of Lys-324, Lys-342, Lys-420, and Phe-421 severely decreased or abolished CYP2E1 recognition by the majority of both the halothane hepatitis and alcoholic liver disease sera, whereas the other substitutions had only minor effects.
|
15456790 |
2004 |
|
Alcoholic Liver Diseases
|
0.300 |
Biomarker
|
group |
BEFREE |
To further evaluate CYP2E1 in alcoholic liver disease, we created a transgenic mouse containing human CYP2E1 complementary DNA (cDNA) under the control of mouse albumin enhancer-promoter.Two experiments were performed.
|
12085356 |
2002 |
|
Alcoholic Liver Diseases
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The ALDH2 genotype is strongly associated with individual alcohol drinking behavior and the development of alcoholic liver disease in Japanese male workers, but the CYP2E1 genotype is not.
|
11410736 |
2001 |
|
Alcoholic Liver Diseases
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In this study, we screened nine exons and exon-intron junctions of the human CYP2E1 gene for detecting allelic variants in genomic DNA samples obtained from 115 Japanese controls, 96 alcoholics, and 44 patients with alcoholic liver diseases.
|
10235271 |
1999 |
|
Alcoholic Liver Diseases
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Monitoring CYP2E1 levels in alcoholic individuals holds inherent appeal because such determinations might indicate individuals at increased risk for alcoholic liver disease.
|
10630604 |
1999 |
|
Alcoholic Liver Diseases
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Polymorphism in the cytochrome P450 2E1 gene and the risk of alcoholic liver disease.
|
9148022 |
1997 |