Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 Biomarker disease RGD CYP2E1 testis expression and alcohol-mediated changes of rat spermatogenesis indices and type I collagen. 23819932 2013
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 Biomarker disease PSYGENET CYP2E1 gene promoter polymorphism -1293G>C increases the risk of essential hypertension in men with alcohol abuse. 24288753 2013
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 Biomarker disease CTD_human Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis. 20843640 2011
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 Biomarker disease PSYGENET Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease. 16425414 2005
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 AlteredExpression disease BEFREE Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease. 16425414 2005
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 Biomarker disease PSYGENET Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse. 11505041 2001
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 AlteredExpression disease BEFREE To further investigate autoantibodies against cytochrome P-450s during alcohol abuse, sera of rats chronically treated with ethanol in the total enteral nutrition model and sera from alcoholics with or without alcohol liver disease and from control subjects were analyzed by enzyme-linked immunosorbent assay and Western blotting for the presence of IgG against rat and human CYP2E1, rat CYP3A1, and human CYP3A4. 9927612 1999
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 Biomarker disease PSYGENET To further investigate autoantibodies against cytochrome P-450s during alcohol abuse, sera of rats chronically treated with ethanol in the total enteral nutrition model and sera from alcoholics with or without alcohol liver disease and from control subjects were analyzed by enzyme-linked immunosorbent assay and Western blotting for the presence of IgG against rat and human CYP2E1, rat CYP3A1, and human CYP3A4. 9927612 1999
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 GeneticVariation disease BEFREE The findings indicate that Caucasians carrying the Rsa I c2 allele of the CYP2E1 gene may be at higher risk of developing ALD if they abuse alcohol. 8747406 1995
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 Biomarker disease PSYGENET The findings indicate that Caucasians carrying the Rsa I c2 allele of the CYP2E1 gene may be at higher risk of developing ALD if they abuse alcohol. 8747406 1995
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.740 AlteredExpression disease BEFREE CYP2E1 expression was not detected in fetal liver, kidney, lung, placenta (18 weeks gestational age) or liver (6 weeks gestational age) obtained at termination of pregnancy where maternal alcohol abuse had been established. 1575782 1992
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease BEFREE By comparing the differences of genotype, allele, and pertinent haplotype frequencies, we did not support a genetic association between CYP2E1 and AD in Han Taiwanese either by single allele tests or haplotype-based analyses. 29588096 2018
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE Our findings suggest that the CAT c.-262C>T genetic polymorphism influences the susceptibility to alcohol dependence and severity of alcohol dependence, while CYP2E1 c.-1053C>T polymorphism influences the expression of obsessive-compulsive and anxiety symptoms. 25514903 2015
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease PSYGENET Our findings suggest that the CAT c.-262C>T genetic polymorphism influences the susceptibility to alcohol dependence and severity of alcohol dependence, while CYP2E1 c.-1053C>T polymorphism influences the expression of obsessive-compulsive and anxiety symptoms. 25514903 2015
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease PSYGENET Two pathological states characterized by CYP2E1 induction were simulated on Wistar male rats: experimental alcoholism and type I diabetes. 25323755 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease PSYGENET We investigated whether variation in genes encoding cytochrome P450 2E1 (CYP2E1) or acetaldehyde-metabolising enzymes (ALDH1A1, ALDH2) might alter the risk of AD, with and without symptoms of anxiety, in a Cape population with mixed ancestry. 24567230 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease PSYGENET First, with the Principle Component analysis, six proteins, CYP2E1, FAM25, CA3, BHMT, HIBADH and ECHS1, involved in oxidation reduction, energy and lipid metabolism and amino acid metabolism, were identified as the most differentially expressed gene products across all of the experimental conditions of our chronic alcoholism model. 24658151 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE We investigated whether variation in genes encoding cytochrome P450 2E1 (CYP2E1) or acetaldehyde-metabolising enzymes (ALDH1A1, ALDH2) might alter the risk of AD, with and without symptoms of anxiety, in a Cape population with mixed ancestry. 24567230 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease BEFREE Thus, genes related to alcohol addiction, such as dopamine receptor D2 in the brain, or liver alcohol-metabolizing enzymes, such as alcohol dehydrogenase class I polypeptide B, cytochrome P450 2E1 and aldehyde dehydrogenase class 2, may vary from one individual to another. 24307790 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease PSYGENET Thus, genes related to alcohol addiction, such as dopamine receptor D2 in the brain, or liver alcohol-metabolizing enzymes, such as alcohol dehydrogenase class I polypeptide B, cytochrome P450 2E1 and aldehyde dehydrogenase class 2, may vary from one individual to another. 24307790 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE Combined linkage and association indicate that sequence changes in or near CYP2E1 affect the level of response to alcohol providing a predictor of risk of alcoholism. 20958328 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease CTD_human Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis. 20843640 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE No significant associations between the 4 polymorphisms of CYP2E1 and alcoholism were revealed by single allele tests. 18034693 2007
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE This documents the presence of a polymorphism of CYP2E1 that is overexpressed in alcoholic Otomies, in which the variant allele (A1 of CYP2E1/TaqI) is associated with increased susceptibility to alcoholism. 17134659 2006
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 Biomarker disease BEFREE Hepatic microsomal cytochrome P450 (CYP2E1), induced in chronic alcohol abuse, is also reported to oxidize ethanol. 16806343 2006