DAPK3, death associated protein kinase 3, 1613

N. diseases: 72; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.010 Biomarker group BEFREE We used Moran's I and Getis-Ord Gi* to evaluate spatial clustering for neural tube defects, critical congenital heart defects (CCHDs), and oral clefts among births whose residence geocoded to the ZIP code or finer level. 31820848 2020
CUI: C0042029
Disease: Urinary tract infection
Urinary tract infection 		0.010 Biomarker group BEFREE Previous resistance, prior prescriptions and patient ZIP code are predictors of subsequent resistance in patients with uncomplicated UTIs. 31747548 2020
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.010 Biomarker phenotype BEFREE Our study demonstrates the significance of DAPK3 in autophagy and GDM, which may provide new insights into the molecular mechanisms regulating trophoblast invasion. 31811899 2020
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.010 GeneticVariation group BEFREE We used Bayesian hierarchical spatiotemporal Poisson regression with conditionally autoregressive spatial effects to assess counts of HCV-related, HIV-related and mental disorder-related hospitalisations at the ZIP code level from 2004 to 2014 in Pennsylvania. 31266767 2019
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.010 Biomarker disease BEFREE No significantly elevated rates of lung or bladder cancer were observed in the affected ZIP codes. 31307340 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.010 Biomarker disease BEFREE No significantly elevated rates of lung or bladder cancer were observed in the affected ZIP codes. 31307340 2019
CUI: C0021831
Disease: Intestinal Diseases
Intestinal Diseases 		0.010 Biomarker group BEFREE Amino acid transporters and ZIP zinc transporters were specifically increased in severe enteropathy, but transcripts for xenobiotic metabolising enzymes were reduced. 31229436 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.010 AlteredExpression disease BEFREE Nine-digit ZIP code level FICO credit scores were appended to individual self-reported chronic diseases (obesity, diabetes, hypertension) and related health behaviours (smoking, exercise, and salt intake and medication adherence among those with hypertension). 30322882 2019
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders 		0.010 GeneticVariation group BEFREE We used Bayesian hierarchical spatiotemporal Poisson regression with conditionally autoregressive spatial effects to assess counts of HCV-related, HIV-related and mental disorder-related hospitalisations at the ZIP code level from 2004 to 2014 in Pennsylvania. 31266767 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.010 AlteredExpression disease BEFREE Zn<sup>2+</sup> transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers, in particular, ZIP4 up-regulation in pancreatic cancer (PC). 31636470 2019
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.010 AlteredExpression phenotype BEFREE Herein, we demonstrated increased expression of DAPK3 in the aortas of VC rats and VSMCs cultured in calcifying media. 30851272 2019
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.010 AlteredExpression disease BEFREE Zn<sup>2+</sup> transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers, in particular, ZIP4 up-regulation in pancreatic cancer (PC). 31636470 2019
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.010 Biomarker disease BEFREE No significantly elevated rates of lung or bladder cancer were observed in the affected ZIP codes. 31307340 2019
CUI: C1704436
Disease: Peripheral Arterial Diseases
Peripheral Arterial Diseases 		0.010 Biomarker group BEFREE We sought to determine whether the Distressed Communities Index (DCI), a composite socioeconomic ranking by ZIP code, could predict short- and long-term outcomes for patients with peripheral artery disease. 31204218 2019
CUI: C4025272
Disease: Peripheral arterial stenosis
Peripheral arterial stenosis 		0.010 Biomarker disease BEFREE We sought to determine whether the Distressed Communities Index (DCI), a composite socioeconomic ranking by ZIP code, could predict short- and long-term outcomes for patients with peripheral artery disease. 31204218 2019
CUI: C0009178
Disease: Cocaine withdrawal
Cocaine withdrawal 		0.010 Biomarker disease BEFREE ZIP microinfusions also blocked the expected AMPA/NMDA ratio increase in the NAc following cocaine withdrawal. 30243909 2018
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.010 Biomarker disease BEFREE Four ZIP codes were identified as potential hotspots for HCV transmission. 29596464 2018
CUI: C0242172
Disease: Pelvic Inflammatory Disease
Pelvic Inflammatory Disease 		0.010 Biomarker group BEFREE Patients living in ZIP codes with the lowest median income (<$38,000) had the highest percent of visits with a pelvic inflammatory disease diagnosis; the smallest declines over time were in patients living in ZIP codes with the highest median income (i.e., >$64,000, total percent change, -24.4%; annual percent change, -3.8%; 95% confidence interval, -5.2% to -2.4%). 29045851 2018
CUI: C0242510
Disease: Drug usage
Drug usage 		0.010 Biomarker phenotype BEFREE Hotspots for injecting drug use initiation were defined as ZIP codes with 5 or more persons who began injecting within the previous 6 years. 29596464 2018
CUI: C4324621
Disease: Opioid use disorder
Opioid use disorder 		0.010 Biomarker disease BEFREE We examined Pennsylvania Health Care Cost Containment Council (PHC4) hospital inpatient discharge data at the ZIP code level to measure the geographic growth and spread of OUD as measured by 44 quarters of inpatient hospitalization data (from 2004 through 2014) for the entire state of Pennsylvania (n = 16,275 ZIP codes). 30573021 2018
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.010 Biomarker disease BEFREE Therefore, we examined whether DAPK3 controls the progression of NSCLC using the NSCLC cell line, A549. 28075459 2017
CUI: C0149778
Disease: Soft Tissue Infection
Soft Tissue Infection 		0.010 GeneticVariation group BEFREE Swine exposure and methicillin-resistant Staphylococcus aureus infection among hospitalized patients with skin and soft tissue infections in Illinois: A ZIP code-level analysis. 28772149 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 Biomarker phenotype BEFREE Death-associated protein kinase 3 controls the tumor progression of A549 cells through ERK MAPK/c-Myc signaling. 28075459 2017
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.010 AlteredExpression disease BEFREE Lung cancer cell line H1299, as well as the gene transfection and RNA interference technology were used to build DLK gene overexpression and knockdown cells. 28588700 2017
CUI: C0343401
Disease: MRSA - Methicillin resistant Staphylococcus aureus infection
MRSA - Methicillin resistant Staphylococcus aureus infection 		0.010 GeneticVariation disease BEFREE For every additional large farm (i.e., >1000 swine) per ZIP code, the aOR for MRSA infection was 1.06 (95% CI: 1.04-1.07). 28772149 2017