|
Adenocarcinoma of large intestine
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Ovarian Mucinous Adenocarcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
The initial characterization of tumor-suppressing kinases- in particular members of the protein kinase C (PKC) family, MKK4 of the mitogen-activated protein kinase kinase family, and DAPK3 of the death-associated protein kinase family- laid the foundation for bioinformatic approaches that enable the identification of other tumor-suppressing kinases.
|
30548122 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Women treated with minimally invasive surgery were more often white, privately insured, and from ZIP Codes with higher socioeconomic status, had smaller, lower-grade tumors, and were more likely to have received a diagnosis later in the study period than women who underwent open surgery.
|
30379613 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Although DAPK3 has been implicated as a tumor suppressor, a recent study revealed an oncogenic role of DAPK3.
|
28075459 |
2017 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
The immunohistochemistry results revealed a down-regulation of DAPK3 expression in AKT over-expressed tumors as compared to control tumors.
|
27126362 |
2016 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
ZIPK has been characterized as a tumor suppressor in various tumors, including gastric cancer.
|
25831050 |
2015 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Our results suggest that DAPK3 is a tumor suppressor in which loss-of-function mutations promote increased cell survival, proliferation, cellular aggregation, and increased resistance to chemotherapy.
|
21487036 |
2011 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
DAPK3 and the shared antigens do not represent minor histocompatibility antigens, as their sequences are identical in both donor and tumor.
|
20124481 |
2010 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Furthermore, higher dlk protein expression in the tumor endothelium than in the endothelium of normal adrenal gland implies that dlk may regulate the endothelial function in neuroblastic tumors.
|
15605081 |
2005 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
As zinc is emerging as an important signaling molecule in the development and progression of cancer, the ZnT and ZIP transporters that regulate cellular zinc homeostasis are promising candidates for targeted cancer therapy.
|
29218234 |
2017 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
As zinc is emerging as an important signaling molecule in the development and progression of cancer, the ZnT and ZIP transporters that regulate cellular zinc homeostasis are promising candidates for targeted cancer therapy.
|
29218234 |
2017 |
|
Malignant Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
These DAPK3 mutants have been associated with very low kinase activity, which results in the cellular progression towards cancer.
|
26748242 |
2016 |
|
Primary malignant neoplasm
|
0.050 |
GeneticVariation
|
group |
BEFREE |
These DAPK3 mutants have been associated with very low kinase activity, which results in the cellular progression towards cancer.
|
26748242 |
2016 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
However, recent evidence that DAXX represses several tumor suppressor genes, including the DAPK1 and DAPK3 protein kinases, and is up-regulated in many cancers argues that a pro-survival role may predominate in a cancer context.
|
25903140 |
2015 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Taken together, our study reveals that ZIPK is a pro-oncogenic factor, which promotes cancer metastasis.
|
25831050 |
2015 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
However, recent evidence that DAXX represses several tumor suppressor genes, including the DAPK1 and DAPK3 protein kinases, and is up-regulated in many cancers argues that a pro-survival role may predominate in a cancer context.
|
25903140 |
2015 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Taken together, our study reveals that ZIPK is a pro-oncogenic factor, which promotes cancer metastasis.
|
25831050 |
2015 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Using bioinformatic applications, we have pinpointed DAPK3 (ZIPK) as a novel cancer-associated kinase with functional mutations.
|
21487036 |
2011 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Using bioinformatic applications, we have pinpointed DAPK3 (ZIPK) as a novel cancer-associated kinase with functional mutations.
|
21487036 |
2011 |
|
Hypertensive disease
|
0.040 |
Biomarker
|
group |
BEFREE |
Death-associated protein kinase 3 (DAPK3) is involved in vascular remodeling in hypertension.
|
30851272 |
2019 |
|
Hypertensive disease
|
0.040 |
GeneticVariation
|
group |
BEFREE |
In adjusted models, each 50-point increase in ZIP code credit score was significantly associated with: 8% lower chronic disease risk; 6% lower overweight/obesity risk, 19% lower diabetes risk; 9% lower hypertension risk and 14% lower smoking risk.
|
30322882 |
2019 |
|
Hypertensive disease
|
0.040 |
Biomarker
|
group |
BEFREE |
Using a co-crystal structure of lead molecule (HS38) in complex with DAPK3, a dual Pim/DAPK3 inhibitor (HS56) and selective DAPK3 inhibitors (HS94 and HS148) were developed to provide mechanistic insight into the polypharmacology of hypertension.
|
30033129 |
2018 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
This suggests that inhibition of DAPK3 may be a contributing factor to the carcinogenesis of the prostate.
|
27126362 |
2016 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis.
|
26117336 |
2015 |