DAXX, death domain associated protein, 1616

N. diseases: 137; N. variants: 2
Disease: Tumor Cell Invasion ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 Biomarker phenotype BEFREE In Cox regression analysis, moderate and poor differentiation (<i>P</i> = 0.006), AJCC stage III/IV (<i>P</i> = 0.013), Enneking stage II/III (<i>P</i> = 0.016), metastasis (<i>P</i> = 0.033), invasion (<i>P</i> = 0.011), and positive DAXX (<i>P</i> = 0.033), and/or DRD3 (<i>P</i> = 0.025) staining correlated negatively with the postoperative survival rate and positively with mortality. 31850367 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 GeneticVariation phenotype BEFREE Moreover, mutations of DAXX were associated with features of malignancy including increased grade, nodal involvement and lymphovascular invasion, and independently predicted both relapse after surgery (p = 0.05) and reduced DFS in multivariable analysis (p = 0.02). 31819132 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 AlteredExpression phenotype BEFREE Under hypoxic conditions, stabilized hypoxia-inducible factor (HIF)-1α downregulates Daxx expression and promotes cancer invasion, whereas re-expression of Daxx represses hypoxia-induced cancer invasion. 28004751 2016