|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
RETRACTED: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in the postmortem frontal cortex from schizophrenia patients.
|
23566496 |
2013 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
BEFREE |
In order to determine whether the mRNA expression levels of Cdc42, Rac1, RhoA, Duo or drebrin are altered in schizophrenia, tissue sections containing DLPFC area 9 from 15 matched pairs of subjects with schizophrenia and control subjects were processed for in situ hybridization.
|
16402129 |
2006 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
In order to determine whether the mRNA expression levels of Cdc42, Rac1, RhoA, Duo or drebrin are altered in schizophrenia, tissue sections containing DLPFC area 9 from 15 matched pairs of subjects with schizophrenia and control subjects were processed for in situ hybridization.
|
16402129 |
2006 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Rats with drebrin A in vivo knockdown displayed a stronger preference for a previous event due to perseverative behavior, impaired pre-pulse inhibition (PPI), increased locomotor activity, anxiety-like behavior, and an increased sensitivity to psychostimulant, suggesting behaviors related to schizophrenia.
|
15140563 |
2004 |
|
Bipolar Disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients.
|
22760556 |
2012 |
|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Dyskinesia, Drug-Induced
|
0.200 |
Biomarker
|
disease |
RGD |
Drebrin immunoreactivity in the striatum of a rat model of levodopa-induced dyskinesia.
|
23241013 |
2013 |
|
Parkinson Disease
|
0.200 |
Therapeutic
|
disease |
RGD |
Immunoelectron microscopic examinations confirmed that drebrin-immunoreactive spines became enlarged in the dopamine-denervated striatum of the levodopa-induced dyskinesia model, but not in the Parkinson's disease model.
|
23241013 |
2013 |
|
Epilepsy, Temporal Lobe
|
0.200 |
Biomarker
|
disease |
RGD |
We used a pathophysiological model of temporal lobe epilepsy induced by pilocarpine in adult rats in order to assess the in vivo role of drebrin A (DA), one of the major regulators of F-actin.
|
21240918 |
2012 |
|
Delirium, Dementia, Amnestic, Cognitive Disorders
|
0.200 |
Biomarker
|
group |
RGD |
Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline.
|
21440628 |
2011 |
|
Sciatic Neuropathy
|
0.200 |
Biomarker
|
disease |
RGD |
Drebrin expression is increased in spinal motoneurons of rats after axotomy.
|
11578820 |
2001 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Changes in drebrin, MAP2 (postsynaptic marker) and synaptophysin (presynaptic marker) in rat brains were examined after 20 min of transient cerebral ischemia.
|
8583659 |
1995 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Drebrin (DBN) regulates cytoskeletal functions during neuronal development, and is thought to contribute to structural and functional synaptic changes associated with aging and Alzheimer's disease.
|
30700723 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
|
29942086 |
2018 |
|
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that AD mice with a low expression of Dbn performed poorly in the behavioral tests and showed decreased glucose utilization.
|
28398234 |
2017 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
(i) The expression of Drebrin is decreased in the hippocampus of aged AD mice compared with that of age-matched WT and young adult AD mice; (ii) cognitive ability of APP/PS1 mice decreases with age; (iii) Drebrin protein expression in the hippocampus correlates with behavioral performance in different aged AD mice; (iv) cognitive ability improved significantly in APP/PS1-Dbn1 mice; (v) the expression level of Drebrin in APP/PS1-Dbn1 mouse hippocampus was significantly increased; (vi) the pathological lesion of AD was alleviated in APP/PS1-Dbn1 mice; (vii) the filamentous actin (F-actin) and microtubule-associated protein 2(MAP-2) in APP/PS1-Dbn1 mice were notably more than control mice.
|
28597477 |
2017 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of the brains of transgenic mice used as models of Alzheimer's disease (AD) reveals that the loss of drebrin from dendritic spines predates the emergence of synaptic dysfunction and cognitive impairment, suggesting that this form of homeostatic plasticity contributes toward cognition.
|
28865018 |
2017 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functionally, loss of drebrin directly correlates with deficits in learning and memory, as is the case observed in Alzheimer's disease.
|
28369888 |
2017 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, we discuss the pathological relevance of drebrin loss in Alzheimer's disease.
|
28199019 |
2017 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Malfunctions of the actin binding protein Drebrin have been implicated in various human diseases such as Alzheimer's disease, cognitive impairments, cancer, and digestive disorders, though with poorly understood mechanisms.
|
28966017 |
2017 |
|
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Drebrin degradation can alter gap junction communication, and drebrin level is decreased in the brain of AD patients.
|
28865023 |
2017 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Indeed, comp-B reduces not only α-synuclein but also insoluble Aβ42 levels, prevents the reductions in synaptophysin and drebrin, and rescues cognitive deficits in transgenic APdE9 mice model of AD.
|
27802241 |
2017 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, immunohistochemistry using postmortem human brains and AD mouse models has shown that drebrin loss in postsynaptic sites occurs earlier than the presynaptic change in AD brains.
|
28865022 |
2017 |
|
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pathology parameters and AD risk were assessed via measurements on plaque burden, levels of phosphorylated glycogen synthase kinase 3-β (GSK3-β), tau, transthyretin and drebrin.
|
24020380 |
2014 |
|
von Willebrand's factor (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
|
23381943 |
2013 |