Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Finally, this paper discusses very recent biological evidence that further supports a role for ACE1 and hypothesises a number of readily testable mechanisms by which the ACE1 enzyme and other components of the renin-angiotensin-aldosterone system may be implicated in increased risk and/or the progression of AD.
|
12806589 |
2003 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data suggest that the ACE allelic variant is not a susceptibility factor in sporadic and familial AD (FAD), nor does it mitigate the effect of the APOE epsilon4 allele in the risk of developing AD.
|
17182125 |
2007 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The risk of AD was also significant for people with ACE DD genotype, D allele, or T-D haplotype [OR (95% CI) = 4.29 (1.96-10.23), 1.90 (1.35-2.70), or 2.91 (1.71-5.10), respectively].
|
16465461 |
2006 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD.
|
15722183 |
2005 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Gender-specific risk for AD has been previously reported, and a biological rationale for involvement of ACE in the AD process is supported by studies exploring the relationship between AD and vascular risk factors such as hypertension.
|
10675799 |
2000 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
CTD_human |
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
|
30820047 |
2019 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD.
|
12928053 |
2003 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Using multivariate logistic regression analysis, we found that in diagnosed AD cases there was a significant interaction between ApoE4 and ACE inhibitor use (odds ratio: 20.85; 95% confidence interval: 3.08-140.95; p = 0.002) after adjusting for age, sex, ethnicity, and education.
|
23567418 |
2014 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This study was aimed to estimate variations of measures of cardiovascular risk in Alzheimer's dementia by pharmacogenetic analyses of the effects of angiotensin-converting enzyme (ACE) inhibitors and statins.
|
31719297 |
2019 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1 (ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and neurodegeneration in Alzheimer's disease (AD).
|
29516284 |
2018 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
CTD_human |
Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population.
|
10643899 |
1999 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that APOE and ACE genotypes may be independent risk factors for late-onset AD, but the ACE association needs to be confirmed in independent samples in which the time and extent of vascular cofactors can be assessed.
|
10681079 |
2000 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the ACE*ins allele was also greater in the groups with Alzheimer's disease and dementia in general (P = 0.022; P = 0.045), but genotype frequencies were only different in groups without the E*4/-317*ins haplotype (P = 0.012 for Alzheimer's disease; P = 0.04 for dementia).
|
21533863 |
2011 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease.
|
29321566 |
2018 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the association between 15 single-nucleotide polymorphisms (SNPs) in DCP1, including the I/D variant, and AD in a sample of 92 patients with AD and 166 nondemented controls from an inbred Israeli Arab community.
|
16642441 |
2006 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Critical review about all studies available on DCP1 genotyping and AD, age-associated cognitive decline, longevity, and other conditions revealed remarkable inconsistencies.
|
11992568 |
2002 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Pharmacogenetics of Angiotensin-Converting Enzyme Inhibitors in Patients with Alzheimer's Disease Dementia.
|
29034839 |
2018 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between angiotensin converting enzyme polymorphism and sporadic Alzheimer's disease.
|
12459519 |
2002 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
LHGDN |
Shifts in angiotensin I converting enzyme insertion allele frequency across Europe: implications for Alzheimer's disease risk.
|
12876265 |
2003 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This suggests a modest but significant increase in risk of AD and early AD pathology in women homozygous for the ACE I-allele independent of vascular factors.
|
15917098 |
2005 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We measured Ang-II and Ang-III levels by ELISA, and the levels and activities of aminopeptidase-A (AP-A) and aminopeptidase-N (AP-N) (responsible for the production and metabolism of Ang-III, respectively) in human postmortem brain tissue in the mid-frontal cortex (Brodmann area 9) in a cohort of AD (n = 90) and age-matched non-demented controls (n = 59), for which we had previous measurements of ACE-1 activity, Aβ level, and tau pathology (also in the mid-frontal cortex).
|
28387670 |
2017 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Cognitive phenotypes in Alzheimer's disease and genetic variants in ACE and IDE.
|
21232820 |
2012 |