Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
DNA polymorphisms of apolipoprotein B and angiotensin I-converting enzyme genes and relationships with lipid levels in Italian patients with vascular dementia or Alzheimer's disease.
|
9681639 |
1998 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
CTD_human |
Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease.
|
9916793 |
1999 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A total of 400 healthy controls younger than 65 years and 350 patients with Alzheimer's disease (average age 72 years) were genotyped for the ACE and ecNOS polymorphisms.
|
10567488 |
1999 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
CTD_human |
Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population.
|
10643899 |
1999 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The altered distribution of ACE alleles in patients with AD appeared to be independent of apolipoprotein E.
|
10643899 |
1999 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Gender-specific risk for AD has been previously reported, and a biological rationale for involvement of ACE in the AD process is supported by studies exploring the relationship between AD and vascular risk factors such as hypertension.
|
10675799 |
2000 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that APOE and ACE genotypes may be independent risk factors for late-onset AD, but the ACE association needs to be confirmed in independent samples in which the time and extent of vascular cofactors can be assessed.
|
10681079 |
2000 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
The ACE gene and Alzheimer's disease susceptibility.
|
10978362 |
2000 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We thus conclude that, in Finns, interaction between DCP1 *I and epsilon4 increases the risk of AD as well as of PD with coexisting Alzheimer pathology, which underlines the importance of the DCP1 I/D polymorphism in the development of Alzheimer neuropathology, whereas the wild type BCHE genotype in combination with epsilon4 had a combined effect with regard to the risk of AD.
|
11015454 |
2000 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In conclusion ACE D and apo epsilon 4 allele were found to be more frequent in patients with Alzheimer's disease than in the control group.
|
11501342 |
2002 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
To determine why ACE affects susceptibility to AD, we examined the effect of purified ACE on aggregation of the amyloid beta-peptide (A beta) in vitro.
|
11604391 |
2001 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The implication of the ACE I/D polymorphism in the pathogenesis of AD warrants further exploration.
|
11803189 |
2002 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Critical review about all studies available on DCP1 genotyping and AD, age-associated cognitive decline, longevity, and other conditions revealed remarkable inconsistencies.
|
11992568 |
2002 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We conclude therefore that the frequency of ACE I-allele is not increased in AD and, in autopsy-confirmed AD cases, possession of the ACE I allele has no impact upon the pathology of AD, at least in terms of the amount of Abeta or tau deposited in the brain.
|
12147333 |
2002 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
LHGDN |
ACE genotypes associated with the risk of AD, but II genotype as risk genetic factor only restricted in subjects with high blood pressure.
|
12362316 |
2002 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Main genes involved in AD include mutational loci (APP, PS1, PS2, TAU) and multiple susceptibility loci (APOE, A2M, AACT, LRP1, IL1A, TNF, ACE, BACE, BCHE, CST3, MTHFR, GSK3B, NOS) distributed across the human genome.
|
12369958 |
2002 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between angiotensin converting enzyme polymorphism and sporadic Alzheimer's disease.
|
12459519 |
2002 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A deletion polymorphism at intron 16 of the ACE gene has also been associated with AD.
|
12480755 |
2002 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
LHGDN |
Further research is needed to elucidate any role that the DCP1 polymorphism may play in relation to Alzheimer's disease.
|
12605101 |
2003 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Further research is needed to elucidate any role that the DCP1 polymorphism may play in relation to Alzheimer's disease.
|
12605101 |
2003 |
Alzheimer's Disease
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Results support a model whereby decreased ACE activity may influence AD susceptibility by a mechanism involving beta-amyloid metabolism.
|
12668609 |
2003 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Finally, this paper discusses very recent biological evidence that further supports a role for ACE1 and hypothesises a number of readily testable mechanisms by which the ACE1 enzyme and other components of the renin-angiotensin-aldosterone system may be implicated in increased risk and/or the progression of AD.
|
12806589 |
2003 |
Alzheimer's Disease
|
0.900 |
GeneticVariation
|
disease |
LHGDN |
Shifts in angiotensin I converting enzyme insertion allele frequency across Europe: implications for Alzheimer's disease risk.
|
12876265 |
2003 |