|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy.
|
7593601 |
1995 |
|
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
CTD_human |
The results indicate that deletion polymorphism in the ACE gene, particularly the homozygote DD, is a risk factor for progression to chronic renal failure in IgA nephropathy.
|
7593601 |
1995 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in angiotensin-converting-enzyme gene and progression of IgA nephropathy.
|
7791440 |
1995 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that 1. the ACE gene polymorphism is not related to the onset of IgA nephropathy, but 2. the progression of IgA nephropathy may be influenced by the polymorphism which may be involved in glomerular hypertension.
|
8529313 |
1995 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined whether the M235T polymorphism of the angiotensinogen (AGT) gene, the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene, and the A1166--> C polymorphism of the angiotensin II type 1 receptor gene may be associated with disease progression in 168 Caucasian patients with IgA nephropathy.
|
9259580 |
1997 |
|
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
CTD_human |
We examined whether the M235T polymorphism of the angiotensinogen (AGT) gene, the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene, and the A1166--> C polymorphism of the angiotensin II type 1 receptor gene may be associated with disease progression in 168 Caucasian patients with IgA nephropathy.
|
9259580 |
1997 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the association between ACE gene polymorphism and clinical findings, early biopsy findings such as the extent of mesangial proliferation, focal lesions (capsular adhesions, glomerulosclerosis, and crescents), and the glomerular area in childhood IgAN.
|
9590186 |
1998 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with the clinico-pathological manifestations in immunoglobulin A nephropathy patients.
|
9594210 |
1997 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that the deletion allele of the insertion/deletion polymorphism of the angiotensin I converting enzyme gene is associated with increased cardiovascular risk and progressive renal disease, including immunoglobulin A nephropathy.
|
10100072 |
1999 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The initial clinical manifestations of both Henoch-Schönlein purpura nephritis and IgA nephropathy were no different among homozygotes for insertion (II) and deletion (DD), and heterozygotes (ID) for the ACE gene.
|
10193250 |
1998 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Angiotensin I-converting enzyme genotype significantly affects progression of IgA glomerulonephritis in an italian population.
|
10352195 |
1999 |
|
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore increased blood bcl-2 concentrations may be considered an index of risk in subjects with IgA nephropathy, and the positive effects of angiotensin-converting enzyme inhibitors on proteinuria in patients with IgA nephropathy may be attributed, at least in part, to their effect on the mechanisms that regulate apoptosis.
|
10391670 |
1999 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that ACE gene polymorphism may be correlated with the prognosis of IgA nephropathy in Japanese children.
|
10404693 |
1999 |
|
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
There were no differences among three genotypes in age, sex, the number of patients with initial blood pressure over 140/90 mmHg, initial serum creatinine level, the number of patients with initial azotemia (> 1.4 mg/dL) and with initial 24-hr proteinuria amount over 2.0 g. Significant anti-proteinuric effect of ACE inhibitor was found in IgAN (p = 0.001), but no significant difference was found among genotypes.
|
10714086 |
2000 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Individuals with IgA nephropathy (IgAN) who are homozygous for the deletion (D) polymorphism of the gene for angiotensin converting enzyme (ACE) are reported to be at increased risk of progressive renal damage.
|
10752761 |
2000 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Insertion/deletion polymorphism in ACE gene is not associated with renal progression in Japanese patients with IgA nephropathy.
|
10793025 |
2000 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The D allele of the angiotensin-converting enzyme (ACE) gene has been linked with diabetic nephropathy and IgA glomerulonephritis and with faster renal disease progression.
|
10821348 |
2000 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We performed an association study of patients with IgA nephropathy and matching control subjects to test whether the G38A polymorphism in the uteroglobin gene, the C2093T polymorphism in the megsin gene, or the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism is associated with IgA nephropathy or rate of disease progression in patients with IgA nephropathy.
|
10977777 |
2000 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We, therefore, investigated the contribution of ACE gene I/D polymorphism in the prognosis of IgAN and its association with the other risk factors affecting the prognosis.
|
11014979 |
2000 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Deletion/insertion polymorphism (D/I) of the angiotensin I converting enzyme gene, M235T polymorphism (T/M) of the angiotensinogen gene and A1166C polymorphism (C/A) of the angiotensin II type 1 receptor gene were determined in 274 Caucasian men with biopsy-proven IgAN (n = 86, 112, and 76 in stages 1, 2, and 3, respectively).
|
11053482 |
2000 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, the TT genotype of the AGT gene and the ID/DD genotype of the ACE gene are associated with increased severity of proteinuria, suggesting that AGT and ACE gene polymorphisms may play a significant role in the progression of IgA nephropathy in Japanese children.
|
11354780 |
2001 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis performed separately for Caucasian and Asian studies showed that the ACE I/D gene polymorphism did not contribute to the genetic susceptibility of the development of IgAN (total OR 0.93, 95% CI, 0.71 to 1.23; and 0.95, 95% CI, 0.64 to 1.42, respectively) or the progression of the renal damage (total OR 1.12, 95% CI, 0.67 to 1.88; and 2.26, 95% CI, 0.75 to 6.79, respectively) in both groups.
|
11473656 |
2001 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among the known gene polymorphism it seems that there is a link between the ACE gene D allele and the progression of IgAN.
|
11783599 |
2002 |
|
IGA Glomerulonephritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Definitive proof of association between ACE gene polymorphism and progression in IgA nephropathy will require a prospective study, controlled for important risk factors, with adequate patient numbers and facility for confirming DD genotypes.
|
12119485 |
2002 |
|
IGA Glomerulonephritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We performed ACE genotyping on 79 patients with IgAN diagnosed prior to age 18 years who had either progressed to end-stage renal disease (ESRD) or are now more than 5 years post biopsy.
|
12172761 |
2002 |