|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The allele frequencies of the apoA-I/C-III, apoB, apoE or ACE gene did not differ between the groups with (n = 148) or without (n = 85) cervical atherosclerosis.
|
9667803 |
1998 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present meta-analysis indicated that the D allele in the ACE gene was associated with the risk of AS, especially in Europeans.
|
30878369 |
2019 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The angiotensin-converting enzyme (ACE) is a rate-limiting enzyme in the renin angiotensin system, the enzyme is involved in the vascular remodelling and atherosclerosis.
|
10653135 |
2000 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results indicated that the DD genotype of the ACE gene could be considered a risk factor for the development of early atherosclerosis in carotid arteries but not for left ventricular hypertrophy in the hypertensive population.
|
10678281 |
2000 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The previously described relationship between heart disease and the ACE-gene polymorphism in diabetes could thus be founded in an increased extent of atherosclerosis among patients with the ID- and DD-ACE-gene subtypes.
|
8781765 |
1996 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A protective role against atherosclerosis can be attributed to angiotensin converting enzyme inhibitors (ACE-I), since they have been shown to reduce mortality in patients at cardiovascular risk.
|
15475831 |
2004 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin-converting enzyme (ACE) a key enzyme in the RAS, plays important roles in vascular remodeling atherosclerosis, and ischemic stroke.
|
30521887 |
2019 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results provide strong evidence that ACE genotype may not be a predictor of either the prevalence or the extent of the lesions of atherosclerosis in the right coronary artery or the aorta of young adults, an observation that confirms previous studies that estimated the prevalence and extent of atherosclerosis using coronary angiography.
|
15694930 |
2005 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the ACE I/D polymorphism does not seem to affect myocardial reactivity--an early indicator of atherosclerosis--in healthy subjects.
|
17852816 |
2007 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The ACE genotype seems to be associated with the echogenicity of carotid artery atheromatosis but not with the common carotid artery intima media thickness or the degree of internal carotid artery stenosis in subjects with type 2 diabetes mellitus.
|
11941276 |
2002 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of Ang II action on the arterial wall by blocking its production with angiotensin converting enzyme (ACE) inhibitors, or by blocking binding to its receptors on cells with antagonists was shown to attenuate atherogenesis in animal model of atherosclerosis.
|
10532681 |
1999 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we investigated the possible association of ACE gene insertion/deletion (I/D) polymorphism and the severity of atherosclerosis, estimated on the basis of the number of coronary stenoses and critical arterial occlusions observed during coronary angiography.
|
18298340 |
2008 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypertension is closely linked to ischaemic stroke (IS) and atherosclerosis, but there are no studies correlating the candidate hypertensive gene, namely angiotensin converting enzyme (ACE) and adducin 1 (ADD1) with magnetic resonance angiographic (MRA) abnormality, therefore this study was undertaken.
|
23540412 |
2013 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, in addition to the markers of insulin resistance and smoking habit, gene variants of PAI-1 and ACE account for a significant portion of the between-individual variability of circulating PAI-1 antigen concentrations in a general population without clinical evidence of atherosclerosis.
|
9555861 |
1998 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 305 individuals were characterized for polymorphisms in eight susceptibility genes for atherosclerosis: ACE, PAI1, NOS3, LTA, FGB, ITGB3, PON1 and APOE.
|
21322770 |
2011 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Kallikrein-1 (KLK1) and angiotensin-converting enzyme (ACE) are 2 key molecules in kallikrein-kinin systems and renin-angiotensin systems, respectively, which are responsible for maintaining vascular balance and stability, playing important roles in atherosclerosis.
|
27858843 |
2016 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the homozygous NOS III variant (GG) status does not seem to interact additively with the ACE homozygous DD genotype in determining flow-mediated vasodilation in individuals with established atherosclerosis and pre-existent endothelial dysfunction.
|
14989558 |
2003 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ACE gene seems to be a candidate for influencing the CIMT and might therefore be involved in an HD patient's predisposition to the development of atherosclerosis.
|
10493570 |
1999 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, the risk of atherosclerosis in hypertensives taking a beta-blocker or ACE-inhibitor-based regimen was not strongly modified by any of the three candidate gene polymorphisms.
|
17298481 |
2007 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Acute ACE inhibition improves coronary epicardial and microvascular endothelium-dependent vasomotion in patients with atherosclerosis or its risk factors who have endothelial dysfunction and presence of the D allele.
|
10880412 |
2000 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between ACE gene I/D polymorphism and risk factor-dependent augmentation of carotid arterial remodeling in subjects with several risk factors for atherosclerosis.
|
12484511 |
2002 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present data suggest that the ACE gene seems to be a candidate gene that strongly influences the IMT of the arterial wall and might therefore be involved in the individual's predisposition to the development of atherosclerosis.
|
8773433 |
1996 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
L-NG monomethyl arginine induced greater constriction in patients with the ACE DD compared with ACE II genotype (coronary blood flow -10 +/- 4% vs. 11 +/- 5%, p = 0.003, ACE DD vs. II and diameter constriction -6.3 +/- 1.2% vs. -1.9 +/- 1.2%, p = 0.01, respectively, in patients with atherosclerosis).
|
11079661 |
2000 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this case-control study was to find relationships between apolipoprotein E (APOE), angiotensin-converting enzyme (ACE), and methylenetetrahydrofolate reductase (MTHFR) genotypes and atherosclerosis of the extracranial internal carotid and intracranial arteries in the Thai population.
|
21296594 |
2012 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The D allele of the ACE I/D polymorphism is known to be associated with an increased incidence of atherosclerosis and has been recently proposed as associated with increased risk of SSc.
|
17264090 |
2007 |