Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, this review summarizes these recent findings for the efficacy of two of the most widely used antihypertensive drug classes, ACE inhibitors and ARBs, to reduce or treat inflammatory diseases such as atherosclerosis, arthritis, steatohepatitis, colitis, pancreatitis, and nephritis.
|
30191985 |
2019 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we sought to assess the impact of myeloid ACE on atherosclerosis.
|
31615657 |
2019 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study indicated that patients with atherosclerosis had higher levels of oxidized Low-Density Lipoprotein (oxLDL) and ACE activity (P < 0.05) as compared to controls.
|
31370787 |
2019 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present meta-analysis indicated that the D allele in the ACE gene was associated with the risk of AS, especially in Europeans.
|
30878369 |
2019 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin-converting enzyme (ACE) a key enzyme in the RAS, plays important roles in vascular remodeling atherosclerosis, and ischemic stroke.
|
30521887 |
2019 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Insertion/deletion polymorphism in ACE gene (ACE I/D) is known to be associated with the occurrence of ischaemic stroke through its effect on pathogenesis of atherosclerosis and hypertension.
|
29199539 |
2018 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The basic factor of cardiovascular diseases is atherosclerosis, which is due largely to an increase in the activity of the angiotensin-converting enzyme (ACE) in vessels.
|
30148999 |
2018 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Regarding pre-hospital medications, atherosclerosis-AHF patients were more likely to be administered nitroglycerin (20.3 vs. 13.7%, p = 0.003), nicorandil (18.8 vs. 7.5%, p < 0.001), angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin II receptor blocker (ARB) (46.5 vs. 38.6%, p = 0.006), β-blocker (33.2 vs. 26.6%, p = 0.014) and statin (30.1 vs. 22.4%, p = 0.003) because of a previous coronary event or atherosclerotic diseases.
|
29943232 |
2018 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased levels of monocytic angiotensin-converting enzyme (ACE) found in haemodialysis (HD) patients may directly participate in the pathogenesis of atherosclerosis.
|
28186543 |
2017 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Angiotensin I converting enzyme (ACE) insertion/deletion (I/D) polymorphism is thought to affect renin-angiotensin system (RAS) activity and development of cardiovascular disease; significant associations between I/D polymorphism and atherosclerosis, stroke, nephropathy, and early mortality were already found.
|
28190172 |
2017 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The eNOS G894T and ACE I/D polymorphisms are associated with an increased risk of developing ACS after adjusting for classical risk factors for atherosclerosis in the Bulgarian cohort.
|
26670794 |
2016 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Kallikrein-1 (KLK1) and angiotensin-converting enzyme (ACE) are 2 key molecules in kallikrein-kinin systems and renin-angiotensin systems, respectively, which are responsible for maintaining vascular balance and stability, playing important roles in atherosclerosis.
|
27858843 |
2016 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two of the 9 SNPs, rs2106261 (16q22) and rs6666258 (1q21), revealed interaction relationships that neared statistical significance (with point estimates in the same direction for angiotensin-converting enzyme inhibitor only and angiotensin II receptor blocker only analyses), but neither association could be replicated among 8,604 participants in Atherosclerosis Risk in Communities.
|
27179719 |
2016 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypertension is closely linked to ischaemic stroke (IS) and atherosclerosis, but there are no studies correlating the candidate hypertensive gene, namely angiotensin converting enzyme (ACE) and adducin 1 (ADD1) with magnetic resonance angiographic (MRA) abnormality, therefore this study was undertaken.
|
23540412 |
2013 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Alu polymorphism of angiotensin I converting enzyme (ACE) and atherosclerosis, incident chronic diseases and mortality in an elderly Chinese population.
|
22456784 |
2012 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this case-control study was to find relationships between apolipoprotein E (APOE), angiotensin-converting enzyme (ACE), and methylenetetrahydrofolate reductase (MTHFR) genotypes and atherosclerosis of the extracranial internal carotid and intracranial arteries in the Thai population.
|
21296594 |
2012 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 305 individuals were characterized for polymorphisms in eight susceptibility genes for atherosclerosis: ACE, PAI1, NOS3, LTA, FGB, ITGB3, PON1 and APOE.
|
21322770 |
2011 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To identify anti-atherogenic target genes, we performed microarray gene expression profiling of the aorta during atherosclerosis prevention with the ACE inhibitor, captopril.
|
20504763 |
2010 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chronic exposure to high levels of circulating and tissue ACE predispose to vascular wall thickening and atherosclerosis.
|
20364300 |
2010 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, development of antagonists or inhibitors of molecules such as peroxisome proliferator-activated receptors (PPARs), lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), angiotensin-converting enzyme (ACE), angiotensin receptors and tumor necrosis factor (TNF)-alpha could be another alternative to prevent atherosclerosis.
|
19754391 |
2009 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Quantitative analysis of immunoreactivity showed that total vessel wall expression of ACE and ACE2 was similar during all stages of atherosclerosis.
|
18498093 |
2008 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we investigated the possible association of ACE gene insertion/deletion (I/D) polymorphism and the severity of atherosclerosis, estimated on the basis of the number of coronary stenoses and critical arterial occlusions observed during coronary angiography.
|
18298340 |
2008 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Early sign of atherosclerosis in slow coronary flow and relationship with angiotensin-converting enzyme I/D polymorphism.
|
17285438 |
2007 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It has been suggested that angiotensin converting enzyme insertion/deletion polymorphism is associated with atherosclerosis.
|
17611909 |
2007 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the ACE I/D polymorphism does not seem to affect myocardial reactivity--an early indicator of atherosclerosis--in healthy subjects.
|
17852816 |
2007 |