ACE, angiotensin I converting enzyme, 1636

N. diseases: 1082; N. variants: 82
Disease: Aortic Stiffness ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3178782
Disease: Aortic Stiffness
Aortic Stiffness 		0.040 GeneticVariation phenotype BEFREE A polymorphism in the angiotensin-converting-enzyme gene (ACE I/D) has been associated with abdominal aortic aneurysm and a link between aortic aneurysm and aortic stiffness has been suggested. 21570325 2011
CUI: C3178782
Disease: Aortic Stiffness
Aortic Stiffness 		0.040 GeneticVariation phenotype BEFREE The aortic stiffness index was statistically different in ACE DD vs. II groups of athletes. 16088128 2005
CUI: C3178782
Disease: Aortic Stiffness
Aortic Stiffness 		0.040 GeneticVariation phenotype BEFREE Influence of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients. 8772690 1996
CUI: C3178782
Disease: Aortic Stiffness
Aortic Stiffness 		0.040 GeneticVariation phenotype BEFREE Since we have recently shown that in hypertensive individuals the A1166C polymorphism of the angiotensin II type 1 receptor (AT1-R) is an independent determinant of aortic stiffness, we designed the present study to assess the influence of this polymorphism on the changes of aortic stiffness after chronic treatment with the angiotensin-converting enzyme inhibitor perindopril and the calcium channel blocker nitrendipine. 8952600 1996