DDT, D-dopachrome tautomerase, 1652

N. diseases: 86; N. variants: 1
Disease: Clinically isolated syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2921627
Disease: Clinically isolated syndrome
Clinically isolated syndrome 		0.010 AlteredExpression disease BEFREE These findings indicate that genetically controlled high MIF expression (and D-DT) promotes MS progression in males, suggesting that these two factors are sex-specific disease modifiers and raising the possibility that aggressive anti-MIF treatment of clinically isolated syndrome or RRMS males with a high-expresser genotype might slow or prevent the onset of progressive MS. Additionally, selective targeting of MIF:CD74 signaling might provide an effective, trackable therapeutic approach for MS subjects of both sexes. 28923927 2017