|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Instead, we observed a nonsignificant decrease in the Hp-1 gene frequency in the DAT population (0.34) as compared to our normal elderly comparison group (0.41).
|
3699841 |
1986 |
|
Leukemia, Myeloid, Chronic-Phase
|
0.010 |
Biomarker
|
disease |
BEFREE |
This myeloid-related sequence (mrs) comprises approximately 2% of the chronic phase, CML mRNA.
|
2893504 |
1987 |
|
Unipolar Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
The frequency of the Hp-1 gene was significantly greater in the patients with major depression (48.6%) than in the normal population (39.0%).
|
8267107 |
1994 |
|
Major Depressive Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The frequency of the Hp-1 gene was significantly greater in the patients with major depression (48.6%) than in the normal population (39.0%).
|
8267107 |
1994 |
|
Adenoviral infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Compared to control, HNP-1 reduced adenoviral infection by more than 95% if administered at 50 microg/ml, and the IC50-value was 15 microg/ml.
|
11495691 |
2001 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cellular necrosis observed in RCC tissues in association with extensive patches of HNP-1, -2, and -3, seemed to be related to high concentrations of alpha-defensins.
|
11943716 |
2002 |
|
Infection
|
0.030 |
AlteredExpression
|
group |
LHGDN |
CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition.
|
12767998 |
2003 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
LHGDN |
Intraarticular release and accumulation of defensins and bactericidal/permeability-increasing protein in patients with rheumatoid arthritis.
|
12913926 |
2003 |
|
Fetal Diseases
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Antimicrobial peptides in amniotic fluid: defensins, calprotectin and bacterial/permeability-increasing protein in patients with microbial invasion of the amniotic cavity, intra-amniotic inflammation, preterm labor and premature rupture of membranes.
|
12710851 |
2003 |
|
Inflammation
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis.
|
15208269 |
2004 |
|
Myeloid Leukemia, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Monomethylated and in particular, dimethylated H3K9 are present to variable degrees in the granulocytes of chronic myeloid leukemia (CML) patients, without being accompanied by HP1 proteins.
|
15507473 |
2005 |
|
Respiratory Tract Infections
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study.
|
16700921 |
2006 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Alpha-defensins 1-3 (human neutrophil peptides [HNP]1-3), reported to be elevated in tumor tissue and serum of patients with colorectal cancer (CRC), have not been studied in stool.
|
17531545 |
2007 |
|
Influenza
|
0.010 |
Biomarker
|
disease |
LHGDN |
Treatment of cell cultures with HNP-1 soon after infection resulted in marked inhibition of influenza virus replication and viral protein synthesis.
|
17703413 |
2007 |
|
Infection
|
0.030 |
Biomarker
|
group |
LHGDN |
Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells.
|
18782756 |
2008 |
|
Infection
|
0.030 |
Biomarker
|
group |
LHGDN |
Mechanism of adenovirus neutralization by Human alpha-defensins.
|
18191790 |
2008 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Human Neutrophil Peptides 1-3--early markers in development of colorectal adenomas and carcinomas.
|
18957723 |
2008 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
LHGDN |
Increased levels of alpha-defensin (-1, -2 and -3) in type 1 diabetic patients with nephropathy.
|
18003664 |
2008 |
|
Leg Ulcer
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Increased levels of human neutrophil alpha-defensins in chronic venous leg ulcers.
|
18472248 |
2008 |
|
Bacterial Vaginosis
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery.
|
18757648 |
2008 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Loss of HP1 proteins causes chromosome segregation defects and lethality in some organisms; a reduction in levels of HP1 family members is associated with cancer progression in humans.
|
18926834 |
2008 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
We have shown that Arf6 and its effector AMAP1 (DDEF1, DEF1, ASAP1 and centaurin beta4) are abnormally overexpressed in some breast cancers and used for their invasion and metastasis.
|
19416474 |
2009 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
We have shown that Arf6 and its effector AMAP1 (DDEF1, DEF1, ASAP1 and centaurin beta4) are abnormally overexpressed in some breast cancers and used for their invasion and metastasis.
|
19416474 |
2009 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We have shown that Arf6 and its effector AMAP1 (DDEF1, DEF1, ASAP1 and centaurin beta4) are abnormally overexpressed in some breast cancers and used for their invasion and metastasis.
|
19416474 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sera from SLE patients and healthy controls were tested for pro-inflammatory human beta-defensin 2 (hBD-2) and for alpha-defensin human neutrophil peptide 1 (HNP-1). hBD-2 could not be detected by enzyme-linked immunosorbent assay (ELISA) and its mRNA levels were low in SLE patients and similar to those found in controls.
|
19191901 |
2009 |