|
Crohn Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Alpha-defensins (α-Defs) in Crohn's disease: decrease of ileal α-Def 5 via permanent methylation and increase in plasma α-Def 1-3 concentrations offering biomarker utility.
|
29193023 |
2018 |
|
Crohn Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Higher DEFA1A3 gene copy number (CD: mean copy number, 7.2 vs. controls 6.7; P < 0.001) and individual DEFA1 alleles (CD mean copy number 5.6 vs. controls 5.1; P < 0.01) were associated with CD, with strong association with colonic location (P < 0.001).
|
21701837 |
2011 |
|
Crohn Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
HNP-1 secretion depends on NOD2 stimulation by MDP-LD and contributes to antibacterial activity in intestinal epithelial cells expressing endogenous NOD2, but not NOD2 3020insC mutant associated with increased susceptibility to Crohn's disease.
|
19856414 |
2010 |
|
Infection
|
0.030 |
Biomarker
|
group |
LHGDN |
Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells.
|
18782756 |
2008 |
|
Infection
|
0.030 |
Biomarker
|
group |
LHGDN |
Mechanism of adenovirus neutralization by Human alpha-defensins.
|
18191790 |
2008 |
|
Infection
|
0.030 |
AlteredExpression
|
group |
LHGDN |
CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition.
|
12767998 |
2003 |
|
Colitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Injections of DEFA1 reduced the severity of spontaneous enteritis and DSS-induced colitis in Atf4ΔIEC mice.
|
30452920 |
2019 |
|
Malignant transformation
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Inflammatory regulation of HNP-1 in PDAC tissue and cells indicates that HNP-1 may be a link between chronic inflammation and malignant transformation in the pancreas.
|
29683978 |
2018 |
|
Coronary heart disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
PPBP and DEFA1/DEFA3 genes in hyperlipidaemia as feasible synergistic inflammatory biomarkers for coronary heart disease.
|
28420383 |
2017 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
There was no observable influence of HNP-1 and LL-37 on tumor cell migration.
|
28910167 |
2017 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The levels of hBD-2 and HNP 1-3 were significantly elevated in the sera and in the CSF of the AD patients These data suggest that both defensin β-2 and α-defensins have potential role in the development of AD.
|
27082275 |
2016 |
|
Colitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Low physiological concentrations of HNP-1 did not significantly affect the expression levels of IL-1β, TNF-α, IL-6 or IL-10 in colonic lamina propria mononuclear cells activated with heat-killed Escherichia coli, suggesting that the anti-inflammatory effects of HNP-1 on murine colitis may not be exerted by direct action on intestinal macrophages.
|
27840892 |
2016 |
|
Coronary heart disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
CHD development moderately correlated with α-defensin mRNA expression (r = 0.429, p = 0.023) and with plasma HNP 1-3 levels (r = 0.486, p = 0.000).
|
27430968 |
2016 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In addition, we demonstrate that LysPG formation is essential for L. monocytogenes survival in the presence of increased osmolytic stress but has no effect on bacterial adherence, invasion or survival in the presence of physiologically relevant concentrations of human neutrophil peptide (HNP-1).
|
24603093 |
2014 |
|
Malignant transformation
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
A decreased gene expression of DEFA 1/3 and 4 might protect pleomorphic adenomas from malignant transformation into adenocarcinomas.
|
23050799 |
2012 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
We have shown that Arf6 and its effector AMAP1 (DDEF1, DEF1, ASAP1 and centaurin beta4) are abnormally overexpressed in some breast cancers and used for their invasion and metastasis.
|
19416474 |
2009 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
We have shown that Arf6 and its effector AMAP1 (DDEF1, DEF1, ASAP1 and centaurin beta4) are abnormally overexpressed in some breast cancers and used for their invasion and metastasis.
|
19416474 |
2009 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Instead, we observed a nonsignificant decrease in the Hp-1 gene frequency in the DAT population (0.34) as compared to our normal elderly comparison group (0.41).
|
3699841 |
1986 |
|
Acute periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Currently, three genes glycosyltransferase 6 domain containing 1 (GLT6D1), defensin α1 and α3 (DEFA1A3), and sialic acid-binding Ig-like lectin 5 (SIGLEC5) that reach the threshold for genomewide significance have been identified as genetic risk factors for AgP through a case-control GWAS.
|
30303256 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, immunohistochemistry was used to analyze the expression of seven anti-microbial peptides (Defensin α1, α4, β1-4 and Cathelicidin) and two secretory proteins with known antimicrobial properties (REG3A and GP2) in pancreatic and duodenal biopsies from 10 non-diabetic organ donors and one organ donor that died at onset of T1D.
|
31242128 |
2019 |
|
Parasitic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
However, UV strongly activated SA-associated defense responses in def-1 after thrips infestation.
|
30782061 |
2019 |
|
Periodontal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Nonsmoking periodontal disease was associated with an abundance of neutrophil defensin 1 and cathelicidin.
|
30485856 |
2019 |
|
Aggressive Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Currently, three genes glycosyltransferase 6 domain containing 1 (GLT6D1), defensin α1 and α3 (DEFA1A3), and sialic acid-binding Ig-like lectin 5 (SIGLEC5) that reach the threshold for genomewide significance have been identified as genetic risk factors for AgP through a case-control GWAS.
|
30303256 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We thus demonstrate that <i>DEFA1/DEFA3</i> copy number variation strongly modulates sepsis development in vivo and explore a paradigm for the precision treatment of sepsis tailored by individual genetic information.
|
30718392 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We thus demonstrate that <i>DEFA1/DEFA3</i> copy number variation strongly modulates sepsis development in vivo and explore a paradigm for the precision treatment of sepsis tailored by individual genetic information.
|
30718392 |
2019 |