DEFB1, defensin beta 1, 1672

N. diseases: 177; N. variants: 8
Disease: Respiratory Tract Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035243
Disease: Respiratory Tract Infections
Respiratory Tract Infections 		0.020 GeneticVariation group LHGDN Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study. 16700921 2006
CUI: C0035243
Disease: Respiratory Tract Infections
Respiratory Tract Infections 		0.020 AlteredExpression group BEFREE In the nasal epithelial cells of HIV-negative patients who suffered from respiratory infections beta-defensin levels were decreased. beta-defensin 1 mRNA expression was significantly reduced in alveolar macrophages from HIV infected patients. beta-defensin 2 mRNA expression in alveolar macrophages was very low. beta-defensins 1 and 2 mRNA expression did not correlate with CD 4 cell numbers in the blood of HIV-infected patients. 15737946 2005