Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 Biomarker disease BEFREE ADAMTS18 deficiency promotes atherosclerosis in apolipoprotein E-deficient mice. 29169989 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 Biomarker disease BEFREE ADAMTS18 deficiency promotes atherosclerosis in apolipoprotein E-deficient mice. 29169989 2018
CUI: C0005938
Disease: Bone Density
Bone Density 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. 19249006 2009
CUI: C0177804
Disease: Bone Mineral Density Test
Bone Mineral Density Test 		0.100 GeneticVariation phenotype GWASDB Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. 19249006 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 Biomarker disease BEFREE Nude mouse model further confirmed that ADAMTS18 suppressed breast cancer metastasis in vivo. 28503860 2017
CUI: C0426429
Disease: Broad nasal tip
Broad nasal tip 		0.100 Biomarker phenotype HPO
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 Biomarker phenotype BEFREE We previously found ADAMTS18 as frequently methylated tumor suppressor gene (TSG) for multiple carcinomas, however, its biological functions and underlying molecular mechanisms in breast carcinogenesis remain unknown. 28503860 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 AlteredExpression phenotype BEFREE In summary, epigenetic regulation of ADAMTS18 was associated with carcinogenesis. 19806480 2010
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 Biomarker phenotype BEFREE These data indicate that Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/β-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in this mouse model. 28145888 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 Biomarker phenotype BEFREE We conclude that ADAMTS18 gene hypermethylation may be involved in the tumorigenesis of ccRCC and may serve as a novel biomarker for this disease. 25569086 2015
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.020 Biomarker group BEFREE We previously found ADAMTS18 as frequently methylated tumor suppressor gene (TSG) for multiple carcinomas, however, its biological functions and underlying molecular mechanisms in breast carcinogenesis remain unknown. 28503860 2017
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.020 Biomarker group BEFREE Thus, through functional epigenetics, we identified ADAMTS18 as a novel functional tumor suppressor, being frequently inactivated epigenetically in multiple carcinomas. 17546048 2007
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.010 Biomarker disease BEFREE Our study suggests that ADAMTS18 promoter methylation is a potential epigenetic biomarker for early detection of lung cancer and warrants investigation as a therapeutic target for early-stage lung cancer. 30417422 2019
CUI: C1449563
Disease: Cardiomyopathy, Familial Idiopathic
Cardiomyopathy, Familial Idiopathic 		0.010 Biomarker disease BEFREE ADAMTS18/20 was significantly associated with histological grade of IDC. 29860265 2018
CUI: C0007274
Disease: Carotid Artery Thrombosis
Carotid Artery Thrombosis 		0.010 Biomarker disease BEFREE ADAMTS18 deficiency accelerated FeCl<sub>3</sub>-induced carotid artery thrombosis and aggravated postischemic cerebral infarction in mice. 29421655 2018
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.010 Biomarker disease BEFREE ADAMTS18 deficiency accelerated FeCl<sub>3</sub>-induced carotid artery thrombosis and aggravated postischemic cerebral infarction in mice. 29421655 2018
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.010 Biomarker disease BEFREE Multivariate analysis demonstrated that ADAMTS18 was an independent prognostic factor for cervical cancer. 28362704 2018
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.010 Biomarker disease BEFREE Multivariate analysis demonstrated that ADAMTS18 was an independent prognostic factor for cervical cancer. 28362704 2018
CUI: C0521683
Disease: Chorioretinal degeneration
Chorioretinal degeneration 		0.100 Biomarker disease HPO
CUI: C0009319
Disease: Colitis
Colitis 		0.010 Biomarker disease BEFREE In AOM/DSS-induced colitis-associated colorectal cancer, the deficiency of Adamts18 in mice resulted in enhanced tumorigenesis and colon inflammation that could be attributed in part to enhanced nuclear translocation of β-catenin and elevated expression of its downstream target genes, cyclin D1 and c-myc. 28145888 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.010 Biomarker disease BEFREE These data indicate that Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/β-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in this mouse model. 28145888 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.310 GeneticVariation disease UNIPROT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.310 Biomarker disease BEFREE Here we generated an Adamts18-deficient mouse strain as an in vivo model to investigate the role of ADAMTS18 in the pathogenesis of colorectal cancer. 28145888 2017
CUI: C4085590
Disease: Cone-Rod Dystrophies
Cone-Rod Dystrophies 		0.010 Biomarker disease BEFREE Physicians should consider screening ADAMTS18 in patients with microcornea and cone-rod dystrophy. 24874986 2014
CUI: C3489532
Disease: Cone-Rod Dystrophy 2
Cone-Rod Dystrophy 2 		0.010 Biomarker disease BEFREE Physicians should consider screening ADAMTS18 in patients with microcornea and cone-rod dystrophy. 24874986 2014