|
MICROCORNEA, MYOPIC CHORIORETINAL ATROPHY, AND TELECANTHUS
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Reassuringly, the autozygomes of all probands overlap on the same chr16q23.1 locus, further supporting the positional mapping of MMCAT to ADAMTS18.
|
23818446 |
2013 |
|
MICROCORNEA, MYOPIC CHORIORETINAL ATROPHY, AND TELECANTHUS
|
0.710 |
GermlineCausalMutation
|
disease |
ORPHANET |
Reassuringly, the autozygomes of all probands overlap on the same chr16q23.1 locus, further supporting the positional mapping of MMCAT to ADAMTS18.
|
23818446 |
2013 |
|
MICROCORNEA, MYOPIC CHORIORETINAL ATROPHY, AND TELECANTHUS
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Reassuringly, the autozygomes of all probands overlap on the same chr16q23.1 locus, further supporting the positional mapping of MMCAT to ADAMTS18.
|
23818446 |
2013 |
|
MICROCORNEA, MYOPIC CHORIORETINAL ATROPHY, AND TELECANTHUS
|
0.710 |
Biomarker
|
disease |
BEFREE |
Reassuringly, the autozygomes of all probands overlap on the same chr16q23.1 locus, further supporting the positional mapping of MMCAT to ADAMTS18.
|
23818446 |
2013 |
|
MICROCORNEA, MYOPIC CHORIORETINAL ATROPHY, AND TELECANTHUS
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
MICROCORNEA, MYOPIC CHORIORETINAL ATROPHY, AND TELECANTHUS
|
0.710 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Colorectal Carcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
Here we generated an Adamts18-deficient mouse strain as an in vivo model to investigate the role of ADAMTS18 in the pathogenesis of colorectal cancer.
|
28145888 |
2017 |
|
Colorectal Carcinoma
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Microcornea
|
0.120 |
Biomarker
|
disease |
BEFREE |
Physicians should consider screening ADAMTS18 in patients with microcornea and cone-rod dystrophy.
|
24874986 |
2014 |
|
Microcornea
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that ADAMTS18 plays an essential role in early eye development and that mutations therein cause a distinct eye phenotype that is mainly characterized by microcornea and myopia.
|
23818446 |
2013 |
|
Microcornea
|
0.120 |
Biomarker
|
disease |
HPO |
|
|
|
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.
|
27114598 |
2016 |
|
Bone Density
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups.
|
19249006 |
2009 |
|
Bone Mineral Density Test
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups.
|
19249006 |
2009 |
|
Telecanthus
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Wide nose
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Broad nasal tip
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Posteriorly rotated ear
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Chorioretinal degeneration
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Thus, our results demonstrated that the tumor suppressor gene ADAMTS18 was downregulated in lung cancer by promoter CpG methylation, and it promoted sensitivity to cisplatin via EGFR/AKT signaling.
|
30417422 |
2019 |
|
Neoplasms
|
0.080 |
PosttranslationalModification
|
group |
BEFREE |
ADAMTS18 promoter methylation was detected in 70.8% of tumor tissues by methylation-specific PCR, but none of the normal tissues.
|
28503860 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
ADAMTS18 is a novel tumor suppressor and is critical to the pathology of human colorectal cancer.
|
28145888 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Furthermore, the methylation status of ADAMTS18 was not significantly associated with gender, age, location, tumor diameter, pathological stage, nuclear grade or short-term DFS in patients with ccRCC (p > 0.05).
|
25569086 |
2015 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
ADAMTS18 is a putative tumor suppressive gene related to nasopharyngeal carcinoma.
|
19806480 |
2010 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In particular, ADAMTS1, ADAMTS9, and ADAMTS18 have been found to be epigenetically silenced in malignant tumors of different sources, suggesting that they may function as tumor suppressor genes.
|
19458070 |
2009 |