DHPS, deoxyhypusine synthase, 1725

N. diseases: 62; N. variants: 1
Disease: Complicated malaria ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2747816
Disease: Complicated malaria
Complicated malaria 		0.010 Biomarker disease BEFREE CNI-1493 prevented infected mice from experimental cerebral malaria by decreasing the levels in hypusinated eIF-5A and serum TNF, implicating a link between cytokine signaling and the hypusine pathway.Therefore we addressed the question whether either DHS itself or eIF-5A is required for the outcome of severe malaria. 22694849 2012