|
Autism Spectrum Disorders
|
0.550 |
Biomarker
|
disease |
BEFREE |
SZ and ASD neurons share a reduced capacity for cortical differentiation as shown by quantitative analysis of the synaptic marker PSD95 and neurite outgrowth.
|
31358727 |
2019 |
|
Autism Spectrum Disorders
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Network analysis of both regions of ASD brain showed up-regulation of multiple pre- and post-synaptic membrane or scaffolding proteins including glutamatergic ion channels and related proteins, up-regulation of proteins involved in intracellular calcium signaling, and down-regulation of neurofilament proteins, with DLG4 and MAPT as major hub proteins in BA19 and CB protein interaction networks, respectively.
|
31511657 |
2019 |
|
Autism Spectrum Disorders
|
0.550 |
Biomarker
|
disease |
BEFREE |
Netrin-G ligand 2 (NGL-2)/LRRC4, implicated in autism spectrum disorders and schizophrenia, is a leucine-rich repeat-containing postsynaptic adhesion molecule that interacts intracellularly with the excitatory postsynaptic scaffolding protein PSD-95 and trans-synaptically with the presynaptic adhesion molecule netrin-G2.
|
29949768 |
2018 |
|
Autism Spectrum Disorders
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders.
|
27271353 |
2016 |
|
Autism Spectrum Disorders
|
0.550 |
Biomarker
|
disease |
CTD_human |
These findings demonstrate that DLG4 gene disruption in mice produces a complex range of behavioral and molecular abnormalities relevant to autism spectrum disorders and Williams' syndrome.
|
20952458 |
2010 |
|
Autism Spectrum Disorders
|
0.550 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate that DLG4 gene disruption in mice produces a complex range of behavioral and molecular abnormalities relevant to autism spectrum disorders and Williams' syndrome.
|
20952458 |
2010 |
|
Autism Spectrum Disorders
|
0.550 |
Biomarker
|
disease |
MGD |
|
|
|
|
Williams Syndrome
|
0.510 |
Biomarker
|
disease |
CTD_human |
The study provides an initial link between human DLG4 gene variation and key neural endophenotypes of Williams' syndrome and perhaps corticoamygdala regulation of emotional and social processes more generally.
|
20952458 |
2010 |
|
Williams Syndrome
|
0.510 |
Biomarker
|
disease |
MGD |
The study provides an initial link between human DLG4 gene variation and key neural endophenotypes of Williams' syndrome and perhaps corticoamygdala regulation of emotional and social processes more generally.
|
20952458 |
2010 |
|
Williams Syndrome
|
0.510 |
GeneticVariation
|
disease |
BEFREE |
The study provides an initial link between human DLG4 gene variation and key neural endophenotypes of Williams' syndrome and perhaps corticoamygdala regulation of emotional and social processes more generally.
|
20952458 |
2010 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study highlights the importance of PSD-95 during neurodevelopment in the mPFC and its potential link in the pathogenesis associated with schizophrenia and/or autism.
|
31263190 |
2019 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This result suggests that PSD95 may be involved in behavioral abnormalities of schizophrenia.
|
31112730 |
2019 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among the results, we found a significant reduction in synaptophysin in schizophrenia in the hippocampus (effect size: -0.65, p < 0.01), frontal (effect size: -0.36, p = 0.04), and cingulate cortices (effect size: -0.54, p = 0.02), but no significant changes for synaptophysin in occipital and temporal cortices, and no changes for SNAP-25, PSD-95, VAMP, and syntaxin in frontal cortex.
|
29511299 |
2019 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we also found nine common DEGs between the mPFC and striatum of <i>Shank3</i> TG mice, among which we further characterized ASD- and SCZ-associated G protein-coupled receptor 85 (<i>Gpr85</i>), encoding an orphan <i>Gpr</i> interacting with PSD-95.
|
30233305 |
2018 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Netrin-G ligand 2 (NGL-2)/LRRC4, implicated in autism spectrum disorders and schizophrenia, is a leucine-rich repeat-containing postsynaptic adhesion molecule that interacts intracellularly with the excitatory postsynaptic scaffolding protein PSD-95 and trans-synaptically with the presynaptic adhesion molecule netrin-G2.
|
29949768 |
2018 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Understanding the role of PSD-95 in the neuropathologies of SCZ and autism will give an insight of the cellular and molecular attributes in the disorders, thus providing treatment options in patients affected.
|
29169997 |
2018 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings describe a unique pathophysiology of specific PSD-95 isoform dysregulation in schizophrenia, chronic neuroleptic treatment, and a genetic lesion mouse model of drastically reduced N-methyl-d-aspartate receptor (NMDAR) complex expression.
|
28126896 |
2017 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have recently reported that protein levels of FRMPD4, a multiscaffolding protein that modulates both Homer1 and postsynaptic density protein 95 activity, is altered in the schizophrenia postmortem brain, in regions involved in cognition.
|
26555035 |
2016 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders.
|
27271353 |
2016 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Changes in cortical N-methyl-D-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide.
|
26013316 |
2016 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although no allelic or genotypic variances of this gene were observed, the possibility that SNPs within DLG4 represent a positive schizophrenia risk gene cannot be excluded.
|
23921260 |
2013 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Although no allelic or genotypic variances of this gene were observed, the possibility that SNPs within DLG4 represent a positive schizophrenia risk gene cannot be excluded.
|
23921260 |
2013 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The DLG4 expression levels between postmortem brain samples from schizophrenia patients showed no significant changes from controls.
|
23936182 |
2013 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
SCZD hiPSC neurons showed diminished neuronal connectivity in conjunction with decreased neurite number, PSD95-protein levels and glutamate receptor expression.
|
21490598 |
2011 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our data indicate that the expression of the DLG4 gene is subject to regulation by the polymorphic markers at the core promoter region, 5' and 3'UTR of the gene, and is associated with the susceptibility of schizophrenia.
|
21151988 |
2010 |