DLG4, discs large MAGUK scaffold protein 4, 1742

N. diseases: 91; N. variants: 54
Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.050 Biomarker phenotype BEFREE It has been suggested that interactions of neuronal nitric oxide synthase (nNOS) with postsynaptic density 95 (PSD95) play important roles in the development of chronic neuropathic pain. 30926374 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.050 Biomarker phenotype BEFREE Specifically, disrupting binding between the enzyme neuronal nitric oxide synthase and either its upstream (postsynaptic density 95 kDa, PSD95) or downstream (e.g. nitric oxide synthase 1 adaptor protein, NOS1AP) protein partners suppressed inflammatory and/or neuropathic pain. 30157705 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.050 Biomarker phenotype BEFREE Postsynaptic density-95 (PSD-95) is a synaptic scaffolding protein that plays a crucial role in the development of neuropathic pain. 29777135 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.050 AlteredExpression phenotype BEFREE Rapamycin reduced mechanical allodynia and downregulated the expression of postsynaptic density protein 95 (PSD95), decreased neural excitability in the IC, thereby inhibiting neuropathic pain-induced synaptic plasticity. 28377693 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.050 Biomarker phenotype BEFREE Perturbing NR2B-PSD-95 interaction relieves neuropathic pain by inactivating CaMKII-CREB signaling. 28746067 2017